MUL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MUL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MUL1 at tissue level.

III. Associated gene sets

GO_1901028Biological processregulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0016925Biological processprotein sumoylation
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0000266Biological processmitochondrial fission
GO_0010821Biological processregulation of mitochondrion organization
GO_0071650Biological processnegative regulation of chemokine (C-C motif) ligand 5 production
GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0000209Biological processprotein polyubiquitination
GO_1904925Biological processpositive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
GO_1903861Biological processpositive regulation of dendrite extension
GO_0031648Biological processprotein destabilization
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0045824Biological processnegative regulation of innate immune response
GO_0033235Biological processpositive regulation of protein sumoylation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0050821Biological processprotein stabilization
GO_0051646Biological processmitochondrion localization
GO_0010637Biological processnegative regulation of mitochondrial fusion
GO_0006915Biological processapoptotic process
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0050689Biological processnegative regulation of defense response to virus by host
GO_0030308Biological processnegative regulation of cell growth
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005777Cellular componentperoxisome
GO_0043025Cellular componentneuronal cell body
GO_0005741Cellular componentmitochondrial outer membrane
GO_0030424Cellular componentaxon
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019789Molecular functionSUMO transferase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0002039Molecular functionp53 binding
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMUL1
Protein nameMitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1)
SynonymsMULAN
RNF218
GIDE
C1orf166
MAPL
DescriptionFUNCTION: Exhibits weak E3 ubiquitin-protein ligase activity . E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates . Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation . Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion . Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations . Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization . Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway . May also be involved in the sumoylation of the membrane fission protein DNM1L . Inhibits cell growth . When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis . Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response . Can mediate RIGI sumoylation and disrupt its polyubiquitination . .

AccessionsENST00000264198.5
Q969V5