Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 10 studies | 28% ± 9% | |
astrocyte | 9 studies | 37% ± 17% | |
microglial cell | 8 studies | 24% ± 7% | |
endothelial cell | 6 studies | 29% ± 9% | |
plasma cell | 5 studies | 34% ± 9% | |
B cell | 5 studies | 26% ± 7% | |
adipocyte | 5 studies | 21% ± 2% | |
fibroblast | 5 studies | 19% ± 4% | |
macrophage | 5 studies | 25% ± 8% | |
oligodendrocyte precursor cell | 4 studies | 31% ± 6% | |
GABAergic neuron | 3 studies | 46% ± 3% | |
glutamatergic neuron | 3 studies | 46% ± 5% | |
ependymal cell | 3 studies | 30% ± 17% | |
ciliated cell | 3 studies | 21% ± 5% | |
monocyte | 3 studies | 18% ± 0% | |
type I pneumocyte | 3 studies | 18% ± 3% | |
interneuron | 3 studies | 37% ± 15% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 6 studies | 35% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1512.72 | 459 / 459 | 100% | 19.30 | 1118 / 1118 |
liver | 100% | 958.78 | 226 / 226 | 100% | 10.77 | 406 / 406 |
ovary | 100% | 1645.19 | 180 / 180 | 100% | 14.67 | 430 / 430 |
prostate | 100% | 1668.51 | 245 / 245 | 100% | 18.22 | 502 / 502 |
stomach | 100% | 1121.75 | 359 / 359 | 100% | 14.90 | 286 / 286 |
thymus | 100% | 1545.38 | 653 / 653 | 100% | 18.92 | 604 / 605 |
lung | 100% | 1349.02 | 577 / 578 | 100% | 14.92 | 1155 / 1155 |
esophagus | 100% | 1523.52 | 1445 / 1445 | 99% | 17.51 | 182 / 183 |
pancreas | 100% | 906.94 | 328 / 328 | 99% | 13.75 | 177 / 178 |
brain | 99% | 711.29 | 2625 / 2642 | 100% | 11.92 | 705 / 705 |
uterus | 100% | 1822.62 | 170 / 170 | 99% | 10.95 | 455 / 459 |
kidney | 100% | 1129.71 | 89 / 89 | 99% | 15.41 | 893 / 901 |
bladder | 100% | 1762.95 | 21 / 21 | 99% | 11.89 | 499 / 504 |
intestine | 100% | 1634.37 | 966 / 966 | 99% | 13.73 | 521 / 527 |
skin | 100% | 1958.75 | 1809 / 1809 | 99% | 12.77 | 466 / 472 |
adrenal gland | 100% | 1382.45 | 258 / 258 | 96% | 10.58 | 220 / 230 |
adipose | 100% | 1415.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1695.45 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 19.08 | 29 / 29 |
spleen | 100% | 1565.41 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.32 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.15 | 1 / 1 |
muscle | 100% | 776.11 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 977.97 | 842 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 10.72 | 78 / 80 |
peripheral blood | 94% | 1028.66 | 871 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006915 | Biological process | apoptotic process |
GO_2000254 | Biological process | regulation of male germ cell proliferation |
GO_0034620 | Biological process | cellular response to unfolded protein |
GO_0031293 | Biological process | membrane protein intracellular domain proteolysis |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_1904211 | Biological process | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol |
GO_0048515 | Biological process | spermatid differentiation |
GO_0043687 | Biological process | post-translational protein modification |
GO_0034644 | Biological process | cellular response to UV |
GO_0036503 | Biological process | ERAD pathway |
GO_0010954 | Biological process | positive regulation of protein processing |
GO_0031966 | Cellular component | mitochondrial membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0044322 | Cellular component | endoplasmic reticulum quality control compartment |
GO_0005515 | Molecular function | protein binding |
GO_0004252 | Molecular function | serine-type endopeptidase activity |
Gene name | RHBDD1 |
Protein name | Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4) Rhomboid domain containing 1 |
Synonyms | HSD50 HSD-50 RHBDL4 |
Description | FUNCTION: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. . |
Accessions | B9A054 ENST00000409053.1 ENST00000424132.1 C9JQK8 C9K011 ENST00000341329.7 [Q8TEB9-1] C9J1R4 ENST00000392062.7 [Q8TEB9-1] ENST00000448992.5 Q8TEB9 ENST00000436481.1 ENST00000437454.5 C9J4C7 ENST00000423616.1 C9JAS2 |