XAF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	34% ± 13%	Explore
natural killer cell	17 studies	26% ± 7%	Explore
non-classical monocyte	13 studies	27% ± 10%	Explore
capillary endothelial cell	13 studies	24% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	27% ± 7%	Explore
macrophage	12 studies	23% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	11 studies	23% ± 7%	Explore
B cell	10 studies	22% ± 6%	Explore
classical monocyte	10 studies	29% ± 9%	Explore
endothelial cell of artery	10 studies	24% ± 7%	Explore
naive B cell	9 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	22% ± 5%	Explore
monocyte	8 studies	27% ± 11%	Explore
gamma-delta T cell	8 studies	21% ± 5%	Explore
regulatory T cell	8 studies	21% ± 5%	Explore
microglial cell	8 studies	25% ± 11%	Explore
memory B cell	7 studies	23% ± 6%	Explore
conventional dendritic cell	6 studies	28% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	23% ± 6%	Explore
mature NK T cell	6 studies	29% ± 7%	Explore
endothelial cell of vascular tree	6 studies	29% ± 11%	Explore
fibroblast	6 studies	22% ± 7%	Explore
T cell	5 studies	25% ± 7%	Explore
CD4-positive, alpha-beta T cell	5 studies	32% ± 16%	Explore
plasmacytoid dendritic cell	5 studies	24% ± 8%	Explore
vein endothelial cell	5 studies	26% ± 6%	Explore
astrocyte	5 studies	24% ± 4%	Explore
ciliated cell	4 studies	18% ± 3%	Explore
myeloid cell	4 studies	24% ± 11%	Explore
dendritic cell	4 studies	29% ± 14%	Explore
hematopoietic stem cell	4 studies	27% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	22% ± 2%	Explore
mucosal invariant T cell	4 studies	22% ± 5%	Explore
secretory cell	3 studies	28% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	23% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
glomerular endothelial cell	3 studies	35% ± 5%	Explore
basal cell	3 studies	24% ± 5%	Explore
lymphocyte	3 studies	24% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
alveolar macrophage	3 studies	23% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	98%	1025.23	1413 / 1445	91%	11.81	167 / 183
ovary	100%	3658.21	180 / 180	85%	7.63	366 / 430
lung	99%	2031.20	574 / 578	78%	6.03	901 / 1155
breast	99%	1645.96	455 / 459	77%	6.24	864 / 1118
stomach	94%	734.86	338 / 359	75%	5.78	214 / 286
uterus	100%	1973.92	170 / 170	68%	6.36	312 / 459
intestine	99%	1024.79	952 / 966	65%	4.42	345 / 527
bladder	95%	1033.86	20 / 21	62%	5.27	314 / 504
kidney	94%	1208.98	84 / 89	58%	4.46	519 / 901
thymus	98%	1159.44	638 / 653	48%	2.20	291 / 605
liver	100%	1595.16	226 / 226	42%	1.89	170 / 406
prostate	99%	1366.23	243 / 245	33%	1.46	165 / 502
skin	76%	465.66	1376 / 1809	52%	4.40	245 / 472
adrenal gland	95%	714.19	246 / 258	30%	1.30	70 / 230
brain	77%	454.96	2039 / 2642	45%	3.21	316 / 705
pancreas	20%	88.56	67 / 328	84%	7.26	150 / 178
spleen	100%	2626.48	241 / 241	0%	0	0 / 0
adipose	100%	1826.02	1198 / 1204	0%	0	0 / 0
heart	99%	1196.46	854 / 861	0%	0	0 / 0
blood vessel	86%	705.44	1148 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	82%	6.44	37 / 45
muscle	69%	297.79	555 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	55%	4.59	16 / 29
peripheral blood	52%	926.75	483 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	14%	0.66	11 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006915	Biological process	apoptotic process
GO_0035456	Biological process	response to interferon-beta
GO_0032480	Biological process	negative regulation of type I interferon production
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0140313	Molecular function	molecular sequestering activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	XAF1
Protein name	XIAP associated factor 1 XIAP-associated factor 1 (BIRC4-binding protein)
Synonyms	BIRC4BP XIAPAF1
Description	FUNCTION: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. .
Accessions	ENST00000346752.8 [Q6GPH4-2] ENST00000575369.5 I3L534 ENST00000571673.1 [Q6GPH4-4] ENST00000571217.5 ENST00000572546.5 Q6GPH4 ENST00000571135.5 C9J7Z8 ENST00000575147.5 I3L2B3 ENST00000574962.5 [Q6GPH4-3] ENST00000574907.5 I3L3D9 I3L3B3 ENST00000576724.5 I3L509 ENST00000574394.5 ENST00000361842.8 [Q6GPH4-1] I3L3Q2

XAF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review