UBE2D3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006281Biological processDNA repair
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0051865Biological processprotein autoubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0036211Biological processprotein modification process
GO_0006915Biological processapoptotic process
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0006513Biological processprotein monoubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0000151Cellular componentubiquitin ligase complex
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005524Molecular functionATP binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE2D3
Protein nameUbiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) (EC 2.3.2.24) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-protein ligase D3)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Ubiquitin conjugating enzyme E2 D3
E2 ubiquitin-conjugating enzyme (EC 2.3.2.23)
SynonymsUBCH5C
UBC5C
DescriptionFUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination . Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation . Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin . Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin . Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA . Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase . Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair . Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus . In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53 . In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes . In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction . Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production . Together with ZNF598, catalyzes ubiquitination of 40S ribosomal proteins in response to ribosome collisions . In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 . .

AccessionsD6RIZ3
ENST00000338145.7 [P61077-1]
ENST00000453744.7 [P61077-1]
ENST00000350435.11
ENST00000394804.6 [P61077-1]
ENST00000502563.5
ENST00000321805.11 [P61077-1]
ENST00000503418.5
D6R9F6
ENST00000394803.9 [P61077-1]
ENST00000514755.5
ENST00000505307.5
ENST00000508249.1
D6R933
ENST00000343106.9 [P61077-2]
ENST00000504211.5
ENST00000508476.5
A0A087WY85
ENST00000394801.8 [P61077-1]
ENST00000507845.5
ENST00000505207.5
ENST00000502690.5
D6RAW0
ENST00000357194.10 [P61077-3]
D6RAH7
D6RJB3
D6RGD0
D6R980
ENST00000508974.5
ENST00000349311.12 [P61077-1]
ENST00000508238.5
D6RA11
ENST00000508635.5
ENST00000510129.5
H9KV45
ENST00000502404.5
P61077
ENST00000618836.4