TOX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0042981Biological processregulation of apoptotic process
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0031490Molecular functionchromatin DNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameTOX3
Protein nameTOX high mobility group box family member 3
TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein)
SynonymsCAGF9
TNRC9
DescriptionFUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. .

AccessionsENST00000568436.1
J3QQQ6
ENST00000219746.14 [O15405-1]
H3BTZ9
ENST00000407228.7 [O15405-2]
ENST00000563091.1
O15405