TCHP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_1902018Biological processnegative regulation of cilium assembly
GO_0030308Biological processnegative regulation of cell growth
GO_0030030Biological processcell projection organization
GO_0005813Cellular componentcentrosome
GO_0030057Cellular componentdesmosome
GO_0005829Cellular componentcytosol
GO_0045095Cellular componentkeratin filament
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0045179Cellular componentapical cortex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTCHP
Protein nameTrichoplein keratin filament binding
Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein)
Synonyms
DescriptionFUNCTION: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells . Is a negative regulator of ciliogenesis . .

AccessionsENST00000536408.2
Q9BT92
F5GWH6
ENST00000312777.9
ENST00000405876.9
ENST00000544838.5