Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 27 studies | 34% ± 17% | |
endothelial cell | 21 studies | 29% ± 12% | |
classical monocyte | 20 studies | 25% ± 8% | |
non-classical monocyte | 20 studies | 40% ± 11% | |
monocyte | 15 studies | 35% ± 17% | |
dendritic cell | 13 studies | 31% ± 9% | |
endothelial cell of artery | 12 studies | 34% ± 14% | |
myeloid cell | 9 studies | 35% ± 12% | |
conventional dendritic cell | 9 studies | 27% ± 7% | |
microglial cell | 8 studies | 32% ± 11% | |
capillary endothelial cell | 7 studies | 26% ± 9% | |
endothelial cell of vascular tree | 7 studies | 22% ± 7% | |
type I pneumocyte | 7 studies | 27% ± 8% | |
ciliated cell | 6 studies | 25% ± 8% | |
mononuclear phagocyte | 5 studies | 43% ± 7% | |
basal cell | 5 studies | 21% ± 4% | |
luminal cell of prostate epithelium | 4 studies | 31% ± 4% | |
neutrophil | 3 studies | 31% ± 12% | |
epithelial cell | 3 studies | 30% ± 9% | |
tissue-resident macrophage | 3 studies | 26% ± 13% | |
GABAergic neuron | 3 studies | 31% ± 9% | |
astrocyte | 3 studies | 29% ± 5% | |
club cell | 3 studies | 27% ± 3% | |
alveolar macrophage | 3 studies | 36% ± 4% | |
leukocyte | 3 studies | 20% ± 5% | |
plasmacytoid dendritic cell | 3 studies | 20% ± 2% | |
interneuron | 3 studies | 26% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 98% | 3443.17 | 239 / 245 | 100% | 57.52 | 502 / 502 |
thymus | 100% | 6698.82 | 652 / 653 | 98% | 69.94 | 590 / 605 |
breast | 99% | 2563.07 | 456 / 459 | 98% | 46.08 | 1093 / 1118 |
kidney | 98% | 2000.44 | 87 / 89 | 92% | 35.71 | 832 / 901 |
lung | 100% | 5159.29 | 578 / 578 | 88% | 23.37 | 1019 / 1155 |
uterus | 91% | 1032.34 | 154 / 170 | 89% | 31.27 | 407 / 459 |
esophagus | 95% | 1318.23 | 1370 / 1445 | 77% | 16.41 | 140 / 183 |
skin | 89% | 3744.95 | 1615 / 1809 | 72% | 15.81 | 341 / 472 |
bladder | 81% | 787.52 | 17 / 21 | 63% | 15.72 | 315 / 504 |
liver | 92% | 1085.12 | 207 / 226 | 51% | 7.27 | 208 / 406 |
ovary | 26% | 233.85 | 46 / 180 | 94% | 36.49 | 405 / 430 |
pancreas | 32% | 228.90 | 106 / 328 | 78% | 12.64 | 139 / 178 |
brain | 58% | 540.16 | 1528 / 2642 | 46% | 5.73 | 325 / 705 |
intestine | 75% | 862.06 | 722 / 966 | 26% | 3.69 | 135 / 527 |
lymph node | 0% | 0 | 0 / 0 | 100% | 49.80 | 29 / 29 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.82 | 1 / 1 |
adipose | 99% | 1970.65 | 1195 / 1204 | 0% | 0 | 0 / 0 |
muscle | 99% | 3324.22 | 795 / 803 | 0% | 0 | 0 / 0 |
spleen | 98% | 3341.99 | 237 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 30.89 | 44 / 45 |
stomach | 61% | 501.50 | 220 / 359 | 35% | 5.70 | 99 / 286 |
heart | 90% | 1007.50 | 771 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 75% | 3426.71 | 701 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 73% | 804.04 | 977 / 1335 | 0% | 0 | 0 / 0 |
adrenal gland | 19% | 142.00 | 50 / 258 | 13% | 1.69 | 30 / 230 |
eye | 0% | 0 | 0 / 0 | 31% | 4.59 | 25 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006915 | Biological process | apoptotic process |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0031966 | Cellular component | mitochondrial membrane |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0031624 | Molecular function | ubiquitin conjugating enzyme binding |
Gene name | RNF144B |
Protein name | E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.31) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein) |
Synonyms | P53RFP IBRDC2 |
Description | FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. . |
Accessions | Q7Z419 ENST00000259939.4 [Q7Z419-1] |