RFFL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001271Biological processnegative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0006915Biological processapoptotic process
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0010762Biological processregulation of fibroblast migration
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0032006Biological processregulation of TOR signaling
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_1901797Biological processnegative regulation of signal transduction by p53 class mediator
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005764Cellular componentlysosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0002020Molecular functionprotease binding
GO_0002039Molecular functionp53 binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRFFL
Protein nameE3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin)
Ring finger and FYVE like domain containing E3 ubiquitin protein ligase
SynonymsRNF189
RNF34L
DescriptionFUNCTION: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. .

AccessionsENST00000315249.11 [Q8WZ73-1]
ENST00000447669.6 [Q8WZ73-1]
Q8WZ73
J3KSI3
ENST00000581265.1
ENST00000584655.5 [Q8WZ73-3]
J3KSU7
ENST00000394597.7 [Q8WZ73-1]
ENST00000581039.1
J3QR17
C9JE27
ENST00000415395.6 [Q8WZ73-1]
ENST00000413582.6 [Q8WZ73-2]
ENST00000582308.1
ENST00000414419.6