Name | Number of supported studies | Average coverage | |
---|---|---|---|
classical monocyte | 4 studies | 20% ± 4% | |
epithelial cell | 4 studies | 34% ± 10% | |
conventional dendritic cell | 3 studies | 31% ± 3% | |
hematopoietic precursor cell | 3 studies | 21% ± 3% | |
precursor B cell | 3 studies | 18% ± 3% | |
ciliated cell | 3 studies | 24% ± 6% | |
GABAergic neuron | 3 studies | 22% ± 5% | |
glutamatergic neuron | 3 studies | 29% ± 7% | |
dendritic cell | 3 studies | 29% ± 4% | |
erythroblast | 3 studies | 32% ± 11% | |
natural killer cell | 3 studies | 22% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5028.01 | 1445 / 1445 | 100% | 120.23 | 183 / 183 |
intestine | 100% | 4552.36 | 966 / 966 | 100% | 97.91 | 527 / 527 |
ovary | 100% | 2798.68 | 180 / 180 | 100% | 70.30 | 430 / 430 |
skin | 100% | 6712.00 | 1809 / 1809 | 100% | 112.53 | 472 / 472 |
stomach | 100% | 4012.91 | 359 / 359 | 100% | 105.39 | 286 / 286 |
lung | 100% | 4252.24 | 578 / 578 | 100% | 91.01 | 1153 / 1155 |
bladder | 100% | 4586.62 | 21 / 21 | 100% | 90.40 | 503 / 504 |
prostate | 100% | 3770.06 | 245 / 245 | 100% | 63.43 | 501 / 502 |
brain | 100% | 3205.23 | 2634 / 2642 | 100% | 80.47 | 705 / 705 |
uterus | 100% | 3742.25 | 170 / 170 | 100% | 79.93 | 457 / 459 |
breast | 100% | 4481.14 | 459 / 459 | 100% | 88.01 | 1113 / 1118 |
thymus | 100% | 4063.77 | 653 / 653 | 99% | 54.59 | 601 / 605 |
pancreas | 100% | 2691.04 | 327 / 328 | 99% | 61.29 | 177 / 178 |
kidney | 100% | 4506.75 | 89 / 89 | 98% | 54.22 | 883 / 901 |
liver | 99% | 2572.86 | 224 / 226 | 97% | 42.42 | 393 / 406 |
adrenal gland | 100% | 4681.41 | 258 / 258 | 94% | 39.79 | 216 / 230 |
adipose | 100% | 4625.76 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 87.00 | 29 / 29 |
muscle | 100% | 4115.40 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4343.29 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 87.08 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 42.01 | 1 / 1 |
blood vessel | 100% | 4417.81 | 1334 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 86.86 | 79 / 80 |
peripheral blood | 97% | 4807.18 | 901 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 2805.60 | 835 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006915 | Biological process | apoptotic process |
GO_2000045 | Biological process | regulation of G1/S transition of mitotic cell cycle |
GO_0010950 | Biological process | positive regulation of endopeptidase activity |
GO_0061136 | Biological process | regulation of proteasomal protein catabolic process |
GO_2001237 | Biological process | negative regulation of extrinsic apoptotic signaling pathway |
GO_0000502 | Cellular component | proteasome complex |
GO_0008537 | Cellular component | proteasome activator complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0061133 | Molecular function | endopeptidase activator activity |
GO_0097371 | Molecular function | MDM2/MDM4 family protein binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0002039 | Molecular function | p53 binding |
Gene name | PSME3 |
Protein name | Proteasome activator complex subunit 3 (Activator of multicatalytic protease subunit 3) (Proteasome activator 28 subunit gamma) Proteasome activator subunit 3 Proteasome activator subunit 3 (cDNA FLJ32659 fis, clone TESTI1000045, highly similar to Proteasome activator complex subunit 3) Proteasome activator subunit 3 (cDNA FLJ57249, highly similar to Proteasome activator complex subunit 3) Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) |
Synonyms | |
Description | FUNCTION: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition . . |
Accessions | ENST00000293362.7 [P61289-2] ENST00000541124.5 K7EPX6 ENST00000590720.6 [P61289-1] B7Z8D3 ENST00000589469.5 K7ESG5 K7EMD0 ENST00000441946.6 [P61289-3] ENST00000586312.5 K7ENH2 K7EKR3 B3KQ25 ENST00000585805.5 ENST00000586114.5 P61289 ENST00000591152.5 ENST00000543428.5 ENST00000545225.5 K7EJF8 K9J957 ENST00000592169.2 Q6FHK7 |