PSME3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0010950Biological processpositive regulation of endopeptidase activity
GO_0061136Biological processregulation of proteasomal protein catabolic process
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0000502Cellular componentproteasome complex
GO_0008537Cellular componentproteasome activator complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061133Molecular functionendopeptidase activator activity
GO_0097371Molecular functionMDM2/MDM4 family protein binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0002039Molecular functionp53 binding

IV. Literature review

[source]
Gene namePSME3
Protein nameProteasome activator complex subunit 3 (Activator of multicatalytic protease subunit 3) (Proteasome activator 28 subunit gamma)
Proteasome activator subunit 3
Proteasome activator subunit 3 (cDNA FLJ32659 fis, clone TESTI1000045, highly similar to Proteasome activator complex subunit 3)
Proteasome activator subunit 3 (cDNA FLJ57249, highly similar to Proteasome activator complex subunit 3)
Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)
Synonyms
DescriptionFUNCTION: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition . .

AccessionsENST00000293362.7 [P61289-2]
ENST00000541124.5
K7EPX6
ENST00000590720.6 [P61289-1]
B7Z8D3
ENST00000589469.5
K7ESG5
K7EMD0
ENST00000441946.6 [P61289-3]
ENST00000586312.5
K7ENH2
K7EKR3
B3KQ25
ENST00000585805.5
ENST00000586114.5
P61289
ENST00000591152.5
ENST00000543428.5
ENST00000545225.5
K7EJF8
K9J957
ENST00000592169.2
Q6FHK7