Name | Number of supported studies | Average coverage | |
---|---|---|---|
CD4-positive, alpha-beta T cell | 16 studies | 23% ± 10% | |
regulatory T cell | 14 studies | 22% ± 7% | |
mucosal invariant T cell | 8 studies | 20% ± 3% | |
CD4-positive, alpha-beta memory T cell | 7 studies | 22% ± 5% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 6 studies | 23% ± 8% | |
T cell | 5 studies | 17% ± 1% | |
glutamatergic neuron | 4 studies | 30% ± 18% | |
T follicular helper cell | 4 studies | 19% ± 4% | |
effector memory CD4-positive, alpha-beta T cell | 4 studies | 28% ± 8% | |
group 3 innate lymphoid cell | 4 studies | 46% ± 4% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 3 studies | 24% ± 12% | |
CD8-positive, alpha-beta T cell | 3 studies | 28% ± 9% | |
endothelial cell | 3 studies | 30% ± 7% | |
macrophage | 3 studies | 19% ± 1% | |
CD4-positive helper T cell | 3 studies | 19% ± 3% | |
T-helper 17 cell | 3 studies | 26% ± 0% | |
T-helper 1 cell | 3 studies | 21% ± 3% |
Insufficient scRNA-seq data for expression of TNFRSF25 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 83% | 672.80 | 150 / 180 | 94% | 13.59 | 406 / 430 |
esophagus | 78% | 1110.02 | 1131 / 1445 | 98% | 14.94 | 180 / 183 |
uterus | 81% | 754.43 | 138 / 170 | 95% | 19.10 | 437 / 459 |
intestine | 79% | 1047.75 | 762 / 966 | 91% | 12.18 | 482 / 527 |
bladder | 71% | 503.19 | 15 / 21 | 96% | 14.05 | 484 / 504 |
lung | 80% | 666.44 | 461 / 578 | 88% | 11.87 | 1012 / 1155 |
adrenal gland | 89% | 902.89 | 229 / 258 | 74% | 10.83 | 171 / 230 |
breast | 92% | 906.42 | 420 / 459 | 71% | 5.85 | 789 / 1118 |
kidney | 92% | 784.11 | 82 / 89 | 58% | 4.75 | 519 / 901 |
thymus | 83% | 673.62 | 540 / 653 | 66% | 5.34 | 402 / 605 |
brain | 85% | 3925.11 | 2243 / 2642 | 53% | 3.36 | 374 / 705 |
prostate | 94% | 1236.42 | 230 / 245 | 35% | 1.84 | 176 / 502 |
stomach | 33% | 183.89 | 117 / 359 | 88% | 11.30 | 252 / 286 |
skin | 73% | 2689.11 | 1317 / 1809 | 29% | 2.09 | 135 / 472 |
spleen | 100% | 6098.03 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.20 | 1 / 1 |
tonsil | 0% | 0 | 0 / 0 | 96% | 17.44 | 43 / 45 |
pancreas | 6% | 32.15 | 19 / 328 | 86% | 8.67 | 153 / 178 |
adipose | 84% | 911.19 | 1011 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 79% | 9.25 | 23 / 29 |
heart | 72% | 579.39 | 623 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 54% | 590.28 | 500 / 929 | 0% | 0 | 0 / 0 |
liver | 8% | 38.61 | 17 / 226 | 41% | 3.19 | 168 / 406 |
blood vessel | 42% | 318.66 | 557 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 6% | 0.33 | 5 / 80 |
muscle | 3% | 14.95 | 26 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0006915 | Biological process | apoptotic process |
GO_0097190 | Biological process | apoptotic signaling pathway |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0033209 | Biological process | tumor necrosis factor-mediated signaling pathway |
GO_0007166 | Biological process | cell surface receptor signaling pathway |
GO_0005829 | Cellular component | cytosol |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0005031 | Molecular function | tumor necrosis factor receptor activity |
GO_0038023 | Molecular function | signaling receptor activity |
Gene name | TNFRSF25 |
Protein name | Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1) TNF receptor superfamily member 25 Tumor necrosis factor receptor superfamily member 25 deletion mutant |
Synonyms | WSL1 DDR3 UNQ455/PRO779 APO3 DR3 TNFRSF12 WSL |
Description | FUNCTION: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. . |
Accessions | ENST00000510563.5 [Q93038-5] ENST00000485036.5 [Q93038-12] ENST00000481401.5 ENST00000351748.7 [Q93038-8] A0A3B3ISD9 ENST00000351959.9 [Q93038-10] Q93038 A0A0C4DGF3 A5LIN1 K7EJY9 ENST00000502588.5 [Q93038-6] ENST00000377782.7 [Q93038-11] ENST00000502730.5 [Q93038-7] ENST00000647810.1 ENST00000348333.7 [Q93038-9] ENST00000414040.6 [Q93038-3] ENST00000356876.8 [Q93038-1] ENST00000480393.5 |