PAK6 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of PAK6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	98%	1088.49	640 / 653	99%	13.18	597 / 605
adrenal gland	93%	1204.09	239 / 258	74%	6.74	170 / 230
brain	89%	3122.85	2354 / 2642	63%	5.11	442 / 705
prostate	69%	739.16	169 / 245	81%	6.69	407 / 502
esophagus	39%	1479.04	557 / 1445	97%	16.27	178 / 183
pancreas	45%	277.75	148 / 328	89%	5.57	159 / 178
lung	29%	197.29	170 / 578	95%	11.06	1099 / 1155
bladder	33%	442.05	7 / 21	90%	10.35	456 / 504
stomach	38%	232.68	135 / 359	81%	5.03	232 / 286
breast	28%	201.78	128 / 459	83%	6.84	928 / 1118
skin	72%	3242.27	1302 / 1809	28%	1.94	133 / 472
tonsil	0%	0	0 / 0	100%	18.78	45 / 45
ureter	0%	0	0 / 0	100%	4.44	1 / 1
kidney	83%	622.12	74 / 89	16%	1.24	142 / 901
ovary	0%	0	0 / 180	97%	8.09	417 / 430
uterus	6%	58.96	10 / 170	89%	16.19	410 / 459
intestine	1%	7.69	13 / 966	87%	5.33	458 / 527
eye	0%	0	0 / 0	71%	3.18	57 / 80
heart	60%	523.51	516 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	34%	2.00	10 / 29
liver	0%	0	0 / 226	11%	0.65	46 / 406
muscle	2%	7.95	13 / 803	0%	0	0 / 0
peripheral blood	1%	5.92	9 / 929	0%	0	0 / 0
blood vessel	0%	2.26	3 / 1335	0%	0	0 / 0
adipose	0%	3.80	2 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

GO_0007612	Biological process	learning
GO_0007010	Biological process	cytoskeleton organization
GO_0035556	Biological process	intracellular signal transduction
GO_0140058	Biological process	neuron projection arborization
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0007613	Biological process	memory
GO_0006915	Biological process	apoptotic process
GO_1990138	Biological process	neuron projection extension
GO_0006468	Biological process	protein phosphorylation
GO_0043408	Biological process	regulation of MAPK cascade
GO_0007626	Biological process	locomotory behavior
GO_0005654	Cellular component	nucleoplasm
GO_0001650	Cellular component	fibrillar center
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0030054	Cellular component	cell junction
GO_0106310	Molecular function	protein serine kinase activity
GO_0045296	Molecular function	cadherin binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	PAK6
Protein name	P21 (RAC1) activated kinase 6 non-specific serine/threonine protein kinase (EC 2.7.11.1) Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
Synonyms	PAK5
Description	FUNCTION: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. .
Accessions	H0YL02 ENST00000560684.6 ENST00000558878.6 ENST00000542403.3 [Q9NQU5-1] H0YK91 Q9NQU5 ENST00000558183.6 H0YK74 ENST00000559139.5 H0YLZ9 ENST00000558658.6 [Q9NQU5-1] ENST00000560669.5 ENST00000453867.7 [Q9NQU5-1] ENST00000558106.5 H0YKB6 H0YK38 H0YL47 ENST00000441369.6 [Q9NQU5-1] ENST00000559617.5 ENST00000560806.6 H0YL16 H0YMS4 ENST00000455577.6 [Q9NQU5-2] ENST00000260404.8 [Q9NQU5-1] ENST00000560346.6 [Q9NQU5-1] H0YM99 ENST00000561230.5 ENST00000558055.5

PAK6 report