PIM3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	35% ± 15%	Explore
endothelial cell of lymphatic vessel	18 studies	35% ± 14%	Explore
B cell	17 studies	25% ± 8%	Explore
basal cell	17 studies	30% ± 13%	Explore
classical monocyte	17 studies	34% ± 13%	Explore
dendritic cell	15 studies	39% ± 19%	Explore
macrophage	15 studies	26% ± 9%	Explore
conventional dendritic cell	15 studies	36% ± 12%	Explore
non-classical monocyte	15 studies	34% ± 15%	Explore
epithelial cell	15 studies	32% ± 17%	Explore
fibroblast	13 studies	26% ± 8%	Explore
plasmacytoid dendritic cell	13 studies	34% ± 12%	Explore
capillary endothelial cell	13 studies	31% ± 12%	Explore
regulatory T cell	13 studies	23% ± 6%	Explore
monocyte	12 studies	30% ± 12%	Explore
T cell	11 studies	23% ± 7%	Explore
secretory cell	11 studies	30% ± 8%	Explore
vein endothelial cell	11 studies	37% ± 10%	Explore
ciliated cell	11 studies	31% ± 13%	Explore
endothelial cell of vascular tree	10 studies	38% ± 11%	Explore
type I pneumocyte	9 studies	32% ± 13%	Explore
club cell	9 studies	29% ± 12%	Explore
CD8-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
natural killer cell	8 studies	24% ± 5%	Explore
type II pneumocyte	8 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	8 studies	23% ± 5%	Explore
memory B cell	8 studies	24% ± 9%	Explore
respiratory goblet cell	7 studies	30% ± 13%	Explore
naive B cell	7 studies	25% ± 3%	Explore
gamma-delta T cell	7 studies	26% ± 8%	Explore
pericyte	7 studies	22% ± 4%	Explore
ionocyte	6 studies	41% ± 10%	Explore
myeloid cell	6 studies	37% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 4%	Explore
smooth muscle cell	6 studies	21% ± 6%	Explore
leukocyte	6 studies	31% ± 10%	Explore
mast cell	5 studies	26% ± 8%	Explore
mononuclear phagocyte	5 studies	32% ± 10%	Explore
goblet cell	5 studies	21% ± 1%	Explore
squamous epithelial cell	4 studies	39% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	31% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	31% ± 14%	Explore
endothelial cell of artery	4 studies	27% ± 5%	Explore
abnormal cell	4 studies	29% ± 9%	Explore
precursor B cell	4 studies	22% ± 3%	Explore
innate lymphoid cell	4 studies	30% ± 5%	Explore
mucus secreting cell	4 studies	22% ± 2%	Explore
adipocyte	4 studies	24% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	33% ± 11%	Explore
T follicular helper cell	4 studies	22% ± 4%	Explore
connective tissue cell	4 studies	22% ± 6%	Explore
plasma cell	3 studies	29% ± 11%	Explore
duct epithelial cell	3 studies	33% ± 2%	Explore
hillock cell	3 studies	19% ± 2%	Explore
neutrophil	3 studies	29% ± 10%	Explore
pancreatic A cell	3 studies	20% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	23% ± 2%	Explore
glomerular endothelial cell	3 studies	27% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	21% ± 5%	Explore
extravillous trophoblast	3 studies	50% ± 4%	Explore
mucosal invariant T cell	3 studies	27% ± 7%	Explore
immature B cell	3 studies	28% ± 7%	Explore
pro-B cell	3 studies	33% ± 12%	Explore
serous secreting cell	3 studies	31% ± 11%	Explore
CD4-positive helper T cell	3 studies	27% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	32% ± 13%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	22% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	28% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	24% ± 10%	Explore
peripheral blood	7 studies	28% ± 8%	Explore
intestine	5 studies	19% ± 4%	Explore
placenta	4 studies	34% ± 12%	Explore
uterus	4 studies	28% ± 13%	Explore
lymph node	4 studies	19% ± 3%	Explore
breast	4 studies	28% ± 8%	Explore
pancreas	3 studies	25% ± 6%	Explore
prostate	3 studies	30% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	5012.86	170 / 170	100%	167.29	458 / 459
thymus	100%	6577.77	652 / 653	100%	93.33	603 / 605
esophagus	100%	5103.32	1438 / 1445	100%	177.36	183 / 183
kidney	100%	10934.19	89 / 89	99%	136.87	895 / 901
lung	100%	11951.85	578 / 578	99%	178.51	1147 / 1155
stomach	100%	9508.06	359 / 359	99%	158.69	284 / 286
bladder	100%	8405.24	21 / 21	99%	154.25	499 / 504
prostate	100%	10399.39	244 / 245	99%	207.29	499 / 502
intestine	99%	5131.32	956 / 966	100%	164.68	525 / 527
breast	100%	9396.47	459 / 459	98%	130.74	1101 / 1118
adrenal gland	100%	4872.73	258 / 258	98%	106.88	225 / 230
skin	96%	9291.03	1731 / 1809	100%	152.04	470 / 472
pancreas	95%	4421.84	313 / 328	99%	165.87	177 / 178
ovary	98%	3801.96	177 / 180	96%	75.42	412 / 430
liver	98%	5346.92	221 / 226	95%	79.20	387 / 406
brain	83%	2035.26	2205 / 2642	82%	40.50	579 / 705
adipose	100%	9836.83	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	140.29	80 / 80
lymph node	0%	0	0 / 0	100%	162.31	29 / 29
spleen	100%	8919.14	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	176.46	45 / 45
ureter	0%	0	0 / 0	100%	55.22	1 / 1
muscle	99%	7214.38	798 / 803	0%	0	0 / 0
peripheral blood	98%	7576.82	915 / 929	0%	0	0 / 0
heart	98%	4272.31	844 / 861	0%	0	0 / 0
blood vessel	92%	3093.84	1231 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006915	Biological process	apoptotic process
GO_0061179	Biological process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0006468	Biological process	protein phosphorylation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0046777	Biological process	protein autophosphorylation
GO_0007346	Biological process	regulation of mitotic cell cycle
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005515	Molecular function	protein binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	PIM3
Protein name	non-specific serine/threonine protein kinase (EC 2.7.11.1) Serine/threonine-protein kinase pim-3 (EC 2.7.11.1)
Synonyms
Description	FUNCTION: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. .
Accessions	Q6P2J9 Q86V86 ENST00000360612.5

PIM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review