Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 29 studies | 28% ± 11% | |
| fibroblast | 14 studies | 24% ± 7% | |
| oligodendrocyte | 12 studies | 56% ± 19% | |
| macrophage | 11 studies | 23% ± 7% | |
| non-classical monocyte | 9 studies | 25% ± 11% | |
| mast cell | 9 studies | 23% ± 10% | |
| astrocyte | 8 studies | 26% ± 9% | |
| pericyte | 8 studies | 19% ± 3% | |
| monocyte | 7 studies | 26% ± 7% | |
| endothelial cell of lymphatic vessel | 7 studies | 24% ± 4% | |
| type I pneumocyte | 7 studies | 22% ± 5% | |
| smooth muscle cell | 7 studies | 20% ± 4% | |
| endothelial cell of vascular tree | 7 studies | 24% ± 6% | |
| classical monocyte | 6 studies | 23% ± 6% | |
| glutamatergic neuron | 6 studies | 31% ± 20% | |
| microglial cell | 6 studies | 26% ± 6% | |
| epithelial cell | 6 studies | 34% ± 19% | |
| neuron | 5 studies | 41% ± 16% | |
| basal cell | 5 studies | 23% ± 6% | |
| retinal cone cell | 5 studies | 24% ± 4% | |
| dendritic cell | 5 studies | 25% ± 9% | |
| neutrophil | 5 studies | 20% ± 2% | |
| goblet cell | 5 studies | 29% ± 17% | |
| GABAergic neuron | 5 studies | 36% ± 17% | |
| squamous epithelial cell | 4 studies | 30% ± 20% | |
| retinal bipolar neuron | 4 studies | 28% ± 8% | |
| lymphocyte | 4 studies | 22% ± 6% | |
| retinal rod cell | 4 studies | 24% ± 6% | |
| capillary endothelial cell | 4 studies | 27% ± 4% | |
| hepatocyte | 4 studies | 35% ± 20% | |
| type II pneumocyte | 4 studies | 18% ± 2% | |
| connective tissue cell | 4 studies | 24% ± 2% | |
| oligodendrocyte precursor cell | 4 studies | 29% ± 7% | |
| conventional dendritic cell | 3 studies | 23% ± 5% | |
| hematopoietic precursor cell | 3 studies | 30% ± 4% | |
| glomerular endothelial cell | 3 studies | 16% ± 0% | |
| myeloid cell | 3 studies | 23% ± 3% | |
| plasma cell | 3 studies | 26% ± 0% | |
| retinal pigment epithelial cell | 3 studies | 19% ± 3% | |
| mononuclear phagocyte | 3 studies | 20% ± 5% | |
| ciliated cell | 3 studies | 33% ± 15% | |
| ON-bipolar cell | 3 studies | 34% ± 7% | |
| rod bipolar cell | 3 studies | 36% ± 6% | |
| T cell | 3 studies | 29% ± 19% | |
| naive B cell | 3 studies | 19% ± 4% | |
| pancreatic A cell | 3 studies | 35% ± 17% | |
| hematopoietic stem cell | 3 studies | 26% ± 11% | |
| enteroendocrine cell | 3 studies | 25% ± 4% | |
| myofibroblast cell | 3 studies | 24% ± 7% | |
| interneuron | 3 studies | 46% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2449.01 | 1445 / 1445 | 100% | 18.49 | 183 / 183 |
| ovary | 100% | 3804.79 | 180 / 180 | 100% | 18.77 | 430 / 430 |
| prostate | 100% | 3401.35 | 245 / 245 | 100% | 36.18 | 502 / 502 |
| lung | 100% | 4292.74 | 578 / 578 | 100% | 19.40 | 1154 / 1155 |
| breast | 100% | 3017.53 | 459 / 459 | 100% | 34.87 | 1117 / 1118 |
| brain | 100% | 2577.95 | 2638 / 2642 | 100% | 15.45 | 705 / 705 |
| bladder | 100% | 3242.95 | 21 / 21 | 100% | 21.54 | 503 / 504 |
| thymus | 100% | 2341.80 | 653 / 653 | 100% | 23.60 | 602 / 605 |
| kidney | 100% | 2236.83 | 89 / 89 | 99% | 21.59 | 894 / 901 |
| uterus | 100% | 3956.85 | 170 / 170 | 99% | 23.23 | 455 / 459 |
| intestine | 100% | 3218.97 | 966 / 966 | 99% | 18.57 | 521 / 527 |
| stomach | 100% | 2057.48 | 359 / 359 | 99% | 18.25 | 282 / 286 |
| adrenal gland | 100% | 1889.12 | 258 / 258 | 98% | 15.80 | 226 / 230 |
| skin | 100% | 3308.33 | 1809 / 1809 | 97% | 25.73 | 460 / 472 |
| liver | 100% | 1615.55 | 226 / 226 | 95% | 10.36 | 386 / 406 |
| pancreas | 94% | 953.35 | 309 / 328 | 99% | 21.69 | 177 / 178 |
| adipose | 100% | 2997.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2614.67 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 17.96 | 29 / 29 |
| spleen | 100% | 3161.46 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 18.30 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.47 | 1 / 1 |
| peripheral blood | 100% | 4987.93 | 925 / 929 | 0% | 0 | 0 / 0 |
| heart | 95% | 1242.67 | 819 / 861 | 0% | 0 | 0 / 0 |
| muscle | 94% | 892.99 | 755 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 88% | 8.60 | 70 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006915 | Biological process | apoptotic process |
| GO_0032435 | Biological process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0031519 | Cellular component | PcG protein complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0003676 | Molecular function | nucleic acid binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003712 | Molecular function | transcription coregulator activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | RYBP |
| Protein name | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) Alternative protein RYBP (RING1 and YY1 binding protein, isoform CRA_b) |
| Synonyms | YEAF1 hCG_2043025 DEDAF |
| Description | FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes . May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis . May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 . May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 . . |
| Accessions | ENST00000643872.2 ENST00000628983.2 ENST00000477973.5 L8ECE1 Q8N488 |