AIMP2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AIMP2 at tissue level.

III. Associated gene sets

GO_0006412Biological processtranslation
GO_0006915Biological processapoptotic process
GO_0016567Biological processprotein ubiquitination
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0060510Biological processtype II pneumocyte differentiation
GO_0065003Biological processprotein-containing complex assembly
GO_0017101Cellular componentaminoacyl-tRNA synthetase multienzyme complex
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameAIMP2
Protein nameAminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1)
Aminoacyl tRNA synthetase complex interacting multifunctional protein 2
SynonymsPRO0992
JTV1
DescriptionFUNCTION: Required for assembly and stability of the aminoacyl-tRNA synthase complex . Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. .

AccessionsF8WCL2
A8MU58
ENST00000415999.1
ENST00000223029.8 [Q13155-1]
ENST00000395236.2 [Q13155-2]
Q13155
ENST00000400479.6