RNF183 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RNF183 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF183 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0051865Biological processprotein autoubiquitination
GO_0016567Biological processprotein ubiquitination
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_1902237Biological processpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0000209Biological processprotein polyubiquitination
GO_0005783Cellular componentendoplasmic reticulum
GO_0033106Cellular componentcis-Golgi network membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF183
Protein nameE3 ubiquitin-protein ligase RNF183 (EC 2.3.2.27)
Synonyms
DescriptionFUNCTION: Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins . Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 . May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling . .

AccessionsENST00000489339.2
ENST00000478815.1
Q96D59
ENST00000441031.3
ENST00000416588.2
ENST00000297894.5