UNC5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0038007Biological processnetrin-activated signaling pathway
GO_0033564Biological processanterior/posterior axon guidance
GO_0031175Biological processneuron projection development
GO_0032589Cellular componentneuron projection membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0032809Cellular componentneuronal cell body membrane
GO_0005042Molecular functionnetrin receptor activity

IV. Literature review

[source]
Gene nameUNC5A
Protein nameUnc-5 netrin receptor A
Netrin receptor UNC5
UNC5A protein
Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A)
SynonymsUNC5H1
KIAA1976
DescriptionFUNCTION: Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. .

FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. .

AccessionsQ05BS3
H0Y9G2
H0Y8R2
Q6ZN44
ENST00000329542.9 [Q6ZN44-1]
ENST00000513890.1
ENST00000509580.2
Q08E75