PACS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0072659Biological processprotein localization to plasma membrane
GO_0032469Biological processendoplasmic reticulum calcium ion homeostasis
GO_0000045Biological processautophagosome assembly
GO_1990456Biological processmitochondrion-endoplasmic reticulum membrane tethering
GO_0005783Cellular componentendoplasmic reticulum
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding
GO_0044325Molecular functiontransmembrane transporter binding

IV. Literature review

[source]
Gene namePACS2
Protein namePhosphofurin acidic cluster sorting protein 2
Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)
SynonymsPACS1L
KIAA0602
DescriptionFUNCTION: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. .

AccessionsENST00000447393.6 [Q86VP3-2]
ENST00000686461.1
A0A8I5KQA5
ENST00000547217.5
F8VW41
ENST00000325438.12 [Q86VP3-1]
ENST00000685365.1
ENST00000430725.6 [Q86VP3-4]
Q86VP3
A0A8I5QJV1