MYO18A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903028Biological processpositive regulation of opsonization
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0043030Biological processregulation of macrophage activation
GO_0090164Biological processasymmetric Golgi ribbon formation
GO_0031032Biological processactomyosin structure organization
GO_0048194Biological processGolgi vesicle budding
GO_0050714Biological processpositive regulation of protein secretion
GO_0007030Biological processGolgi organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006259Biological processDNA metabolic process
GO_0006915Biological processapoptotic process
GO_0016477Biological processcell migration
GO_0090161Biological processGolgi ribbon formation
GO_0032982Cellular componentmyosin filament
GO_0016020Cellular componentmembrane
GO_0005815Cellular componentmicrotubule organizing center
GO_0005802Cellular componenttrans-Golgi network
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0016460Cellular componentmyosin II complex
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005737Cellular componentcytoplasm
GO_0042641Cellular componentactomyosin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0043531Molecular functionADP binding
GO_0051015Molecular functionactin filament binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameMYO18A
Protein nameMyosin XVIIIA
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)
Putative TGFB1-induced anti-apoptotic factor 1 (12 kDa TGF-beta-1-induced antiapoptotic factor)
SynonymsTIAF1
MYSPDZ
KIAA0216
CD245
DescriptionFUNCTION: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus . Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration . May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking . Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages . Strongly enhances natural killer cell cytotoxicity . .

FUNCTION: [Isoform TIAF1]: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. .

AccessionsENST00000530254.6
O95411
ENST00000533420.3
ENST00000528564.2
A0A1B0GV45
ENST00000704659.1
E9PN42
A0A1B0GWJ6
ENST00000533112.5 [Q92614-3]
A0A994J771
ENST00000588791.1
Q92614
K7EKB3
H0YEV9
ENST00000527372.7 [Q92614-1]
ENST00000636100.1
ENST00000531253.5 [Q92614-4]