ADAM15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADAM15 at tissue level.

III. Associated gene sets

GO_1904628Biological processcellular response to phorbol 13-acetate 12-myristate
GO_0001525Biological processangiogenesis
GO_0002418Biological processimmune response to tumor cell
GO_0045087Biological processinnate immune response
GO_0007160Biological processcell-matrix adhesion
GO_0001953Biological processnegative regulation of cell-matrix adhesion
GO_0022617Biological processextracellular matrix disassembly
GO_0042246Biological processtissue regeneration
GO_0030574Biological processcollagen catabolic process
GO_0060317Biological processcardiac epithelial to mesenchymal transition
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0006508Biological processproteolysis
GO_0030308Biological processnegative regulation of cell growth
GO_0008584Biological processmale gonad development
GO_0006915Biological processapoptotic process
GO_0030336Biological processnegative regulation of cell migration
GO_1900121Biological processnegative regulation of receptor binding
GO_1990910Biological processresponse to hypobaric hypoxia
GO_0005615Cellular componentextracellular space
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0031514Cellular componentmotile cilium
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0005912Cellular componentadherens junction
GO_0008237Molecular functionmetallopeptidase activity
GO_0034987Molecular functionimmunoglobulin receptor binding
GO_0005178Molecular functionintegrin binding
GO_0046872Molecular functionmetal ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameADAM15
Protein nameDisintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
SynonymsMDC15
DescriptionFUNCTION: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. .

AccessionsENST00000529473.5 [Q13444-8]
Q13444
ENST00000271836.10 [Q13444-2]
ENST00000356955.7 [Q13444-1]
ENST00000360674.8 [Q13444-10]
ENST00000368412.7 [Q13444-9]
ENST00000447332.3 [Q13444-13]
ENST00000449910.6 [Q13444-3]
ENST00000526491.5 [Q13444-6]
ENST00000355956.6 [Q13444-4]
ENST00000531455.5 [Q13444-12]
ENST00000368413.5 [Q13444-11]
ENST00000359280.8 [Q13444-5]