Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 33 studies | 35% ± 14% | |
capillary endothelial cell | 14 studies | 34% ± 13% | |
endothelial cell of artery | 12 studies | 47% ± 19% | |
vein endothelial cell | 12 studies | 44% ± 13% | |
classical monocyte | 9 studies | 22% ± 8% | |
endothelial cell of vascular tree | 9 studies | 32% ± 9% | |
endothelial cell of lymphatic vessel | 7 studies | 21% ± 6% | |
conventional dendritic cell | 6 studies | 26% ± 13% | |
basal cell | 6 studies | 26% ± 6% | |
dendritic cell | 5 studies | 29% ± 12% | |
epithelial cell | 5 studies | 30% ± 7% | |
ciliated cell | 4 studies | 26% ± 8% | |
deuterosomal cell | 4 studies | 30% ± 16% | |
goblet cell | 4 studies | 22% ± 3% | |
secretory cell | 3 studies | 36% ± 4% | |
glomerular endothelial cell | 3 studies | 16% ± 0% | |
abnormal cell | 3 studies | 29% ± 9% | |
transit amplifying cell | 3 studies | 25% ± 2% |
Insufficient scRNA-seq data for expression of ADAM15 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 10091.90 | 1445 / 1445 | 100% | 95.10 | 183 / 183 |
stomach | 100% | 6881.68 | 359 / 359 | 100% | 88.60 | 285 / 286 |
prostate | 100% | 9288.22 | 245 / 245 | 100% | 97.40 | 500 / 502 |
uterus | 100% | 8417.22 | 170 / 170 | 100% | 115.19 | 457 / 459 |
breast | 100% | 12909.78 | 459 / 459 | 99% | 139.22 | 1112 / 1118 |
ovary | 99% | 4448.92 | 179 / 180 | 100% | 72.94 | 430 / 430 |
lung | 100% | 10486.45 | 577 / 578 | 99% | 98.27 | 1149 / 1155 |
intestine | 100% | 6693.56 | 966 / 966 | 99% | 102.01 | 523 / 527 |
skin | 100% | 14879.33 | 1805 / 1809 | 99% | 93.44 | 469 / 472 |
bladder | 100% | 7551.90 | 21 / 21 | 98% | 96.86 | 496 / 504 |
thymus | 100% | 7009.98 | 652 / 653 | 95% | 56.64 | 574 / 605 |
brain | 95% | 3820.25 | 2504 / 2642 | 99% | 38.63 | 701 / 705 |
pancreas | 91% | 2818.38 | 299 / 328 | 98% | 88.91 | 175 / 178 |
kidney | 96% | 4226.08 | 85 / 89 | 87% | 35.59 | 784 / 901 |
adrenal gland | 98% | 3554.36 | 254 / 258 | 74% | 27.87 | 170 / 230 |
liver | 58% | 1458.73 | 130 / 226 | 85% | 39.04 | 345 / 406 |
adipose | 100% | 12933.67 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 7941.59 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 97.76 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 62.32 | 1 / 1 |
blood vessel | 100% | 5734.44 | 1329 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 5968.36 | 855 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 40.17 | 78 / 80 |
muscle | 88% | 2638.23 | 705 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 83% | 20.97 | 24 / 29 |
peripheral blood | 71% | 2336.76 | 661 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1904628 | Biological process | cellular response to phorbol 13-acetate 12-myristate |
GO_0001525 | Biological process | angiogenesis |
GO_0002418 | Biological process | immune response to tumor cell |
GO_0045087 | Biological process | innate immune response |
GO_0007160 | Biological process | cell-matrix adhesion |
GO_0001953 | Biological process | negative regulation of cell-matrix adhesion |
GO_0022617 | Biological process | extracellular matrix disassembly |
GO_0042246 | Biological process | tissue regeneration |
GO_0030574 | Biological process | collagen catabolic process |
GO_0060317 | Biological process | cardiac epithelial to mesenchymal transition |
GO_0007229 | Biological process | integrin-mediated signaling pathway |
GO_0006508 | Biological process | proteolysis |
GO_0030308 | Biological process | negative regulation of cell growth |
GO_0008584 | Biological process | male gonad development |
GO_0006915 | Biological process | apoptotic process |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_1900121 | Biological process | negative regulation of receptor binding |
GO_1990910 | Biological process | response to hypobaric hypoxia |
GO_0005615 | Cellular component | extracellular space |
GO_0001669 | Cellular component | acrosomal vesicle |
GO_0005886 | Cellular component | plasma membrane |
GO_0031514 | Cellular component | motile cilium |
GO_0070062 | Cellular component | extracellular exosome |
GO_0009986 | Cellular component | cell surface |
GO_0005912 | Cellular component | adherens junction |
GO_0008237 | Molecular function | metallopeptidase activity |
GO_0034987 | Molecular function | immunoglobulin receptor binding |
GO_0005178 | Molecular function | integrin binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0004222 | Molecular function | metalloendopeptidase activity |
GO_0005515 | Molecular function | protein binding |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | ADAM15 |
Protein name | Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin) |
Synonyms | MDC15 |
Description | FUNCTION: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. . |
Accessions | ENST00000529473.5 [Q13444-8] Q13444 ENST00000271836.10 [Q13444-2] ENST00000356955.7 [Q13444-1] ENST00000360674.8 [Q13444-10] ENST00000368412.7 [Q13444-9] ENST00000447332.3 [Q13444-13] ENST00000449910.6 [Q13444-3] ENST00000526491.5 [Q13444-6] ENST00000355956.6 [Q13444-4] ENST00000531455.5 [Q13444-12] ENST00000368413.5 [Q13444-11] ENST00000359280.8 [Q13444-5] |