DPF1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DPF1 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0070316Biological processregulation of G0 to G1 transition
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045597Biological processpositive regulation of cell differentiation
GO_0007399Biological processnervous system development
GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_2000781Biological processpositive regulation of double-strand break repair
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0006338Biological processchromatin remodeling
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0071565Cellular componentnBAF complex
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDPF1
Protein nameZinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1)
Double PHD fingers 1
DPF1 protein
D4, zinc and double PHD fingers family 1, isoform CRA_c (Double PHD fingers 1)
D4 zinc and double PHD fingers family 1 variant 4 (Double PHD fingers 1)
D4, zinc and double PHD fingers family 1, isoform CRA_b (Zinc finger protein neuro-d4)
Zinc finger protein neuro-d4
SynonymsBAF45B
NEUD4
hCG_42854
DescriptionFUNCTION: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .

AccessionsENST00000438365.5
Q08AJ1
ENST00000414789.5 [Q92782-3]
A0A8I5QL29
ENST00000686058.1
ENST00000418517.5
F8WEC4
ENST00000420980.8 [Q92782-1]
ENST00000689228.1
ENST00000456296.5
C8C3P2
A0A8I5KWI2
ENST00000412732.5 [Q92782-3]
C9IZH8
Q6PJ73
A0A804CYY4
Q92782
ENST00000420980
ENST00000614244.4
ENST00000416611.5
ENST00000355526
C9JGC1
A0A804CCM0
ENST00000355526.10 [Q92782-2]
K7EJD5
J3KQY6
E9PDV3
ENST00000438060.5
ENST00000586624.1