ZNF385A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
conventional dendritic cell	20 studies	33% ± 16%	Explore
classical monocyte	19 studies	33% ± 12%	Explore
non-classical monocyte	17 studies	30% ± 12%	Explore
monocyte	11 studies	25% ± 7%	Explore
dendritic cell	8 studies	47% ± 16%	Explore
retinal rod cell	8 studies	36% ± 22%	Explore
macrophage	8 studies	25% ± 6%	Explore
retinal cone cell	6 studies	54% ± 32%	Explore
myeloid cell	5 studies	27% ± 7%	Explore
basal cell	5 studies	23% ± 4%	Explore
OFF-bipolar cell	4 studies	46% ± 20%	Explore
ON-bipolar cell	4 studies	44% ± 21%	Explore
retinal ganglion cell	4 studies	70% ± 23%	Explore
amacrine cell	4 studies	41% ± 18%	Explore
astrocyte	4 studies	21% ± 5%	Explore
retina horizontal cell	4 studies	44% ± 17%	Explore
retinal bipolar neuron	3 studies	65% ± 19%	Explore
ciliated cell	3 studies	18% ± 3%	Explore
Mueller cell	3 studies	25% ± 9%	Explore
rod bipolar cell	3 studies	48% ± 21%	Explore
intermediate monocyte	3 studies	44% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	6 studies	44% ± 17%	Explore
brain	3 studies	16% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	6328.52	2636 / 2642	100%	146.33	705 / 705
thymus	100%	4866.54	652 / 653	100%	81.84	604 / 605
prostate	99%	4087.13	242 / 245	98%	52.12	490 / 502
breast	98%	2718.03	452 / 459	95%	87.04	1058 / 1118
lung	95%	2258.58	547 / 578	93%	74.91	1071 / 1155
esophagus	93%	4769.42	1345 / 1445	91%	133.90	166 / 183
bladder	95%	4187.52	20 / 21	82%	98.42	413 / 504
skin	73%	11103.35	1323 / 1809	86%	42.35	408 / 472
uterus	41%	676.59	69 / 170	93%	104.07	428 / 459
intestine	74%	1602.56	715 / 966	45%	17.90	236 / 527
kidney	36%	489.54	32 / 89	81%	31.08	726 / 901
ovary	18%	267.97	32 / 180	90%	42.72	389 / 430
adrenal gland	62%	921.50	160 / 258	44%	30.44	102 / 230
ureter	0%	0	0 / 0	100%	21.25	1 / 1
stomach	39%	755.29	140 / 359	59%	24.52	170 / 286
adipose	98%	3250.29	1179 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	139.03	44 / 45
spleen	95%	2325.51	229 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	57.74	26 / 29
peripheral blood	83%	2929.09	774 / 929	0%	0	0 / 0
pancreas	2%	25.55	6 / 328	80%	32.73	143 / 178
blood vessel	58%	1156.70	779 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	57%	23.35	46 / 80
heart	54%	884.69	461 / 861	0%	0	0 / 0
muscle	46%	1132.32	370 / 803	0%	0	0 / 0
liver	3%	43.46	7 / 226	27%	8.65	108 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010609	Biological process	mRNA localization resulting in post-transcriptional regulation of gene expression
GO_0007611	Biological process	learning or memory
GO_0006974	Biological process	DNA damage response
GO_0035855	Biological process	megakaryocyte development
GO_0007599	Biological process	hemostasis
GO_0070889	Biological process	platelet alpha granule organization
GO_1902164	Biological process	positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_0045600	Biological process	positive regulation of fat cell differentiation
GO_1902166	Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0006915	Biological process	apoptotic process
GO_0030220	Biological process	platelet formation
GO_0007626	Biological process	locomotory behavior
GO_2000765	Biological process	regulation of cytoplasmic translation
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0008270	Molecular function	zinc ion binding
GO_0002039	Molecular function	p53 binding
GO_0003723	Molecular function	RNA binding
GO_0003730	Molecular function	mRNA 3'-UTR binding

IV. Literature review

[source]

Gene name	ZNF385A
Protein name	Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) Zinc finger protein 385A
Synonyms	HZF RZF ZNF385
Description	FUNCTION: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. .
Accessions	ENST00000352268.10 [Q96PM9-3] F8VRY0 F8VWV6 ENST00000338010.9 [Q96PM9-4] ENST00000551771.5 [Q96PM9-2] ENST00000550120.1 Q96PM9 ENST00000551109.5 [Q96PM9-1] F8VSJ1 F8VQ24 ENST00000547210.5 ENST00000550774.5 F8VY43 ENST00000549962.5 H0YI55 ENST00000546970.5 [Q96PM9-1] ENST00000550779.5 ENST00000549937.5 H0YIX3 ENST00000546919.5 ENST00000394313.7 [Q96PM9-1]

ZNF385A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review