BIRC6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0008283Biological processcell population proliferation
GO_0051301Biological processcell division
GO_0060711Biological processlabyrinthine layer development
GO_0043066Biological processnegative regulation of apoptotic process
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006468Biological processprotein phosphorylation
GO_0042127Biological processregulation of cell population proliferation
GO_0032465Biological processregulation of cytokinesis
GO_0030496Cellular componentmidbody
GO_0000922Cellular componentspindle pole
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0005815Cellular componentmicrotubule organizing center
GO_0005802Cellular componenttrans-Golgi network
GO_0090543Cellular componentFlemming body
GO_0005829Cellular componentcytosol
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0004869Molecular functioncysteine-type endopeptidase inhibitor activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBIRC6
Protein nameBaculoviral IAP repeat-containing protein 6 (EC 2.3.2.27) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (RING-type E3 ubiquitin transferase BIRC6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)
Baculoviral IAP repeat containing 6
SynonymsKIAA1289
DescriptionFUNCTION: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. .

AccessionsA0A3B3IUB9
H7C3P0
A0A8V8TQB4
ENST00000431454.2
ENST00000700518.1
ENST00000421745.7
ENST00000648282.1
ENST00000444173.5
Q9NR09
H7C094
A0A8V8TR92
ENST00000700519.1