PLSCR3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLSCR3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLSCR3 at tissue level.

III. Associated gene sets

GO_0090199Biological processregulation of release of cytochrome c from mitochondria
GO_0042981Biological processregulation of apoptotic process
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0032049Biological processcardiolipin biosynthetic process
GO_0006915Biological processapoptotic process
GO_0017121Biological processplasma membrane phospholipid scrambling
GO_0042593Biological processglucose homeostasis
GO_0042632Biological processcholesterol homeostasis
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0045340Molecular functionmercury ion binding
GO_0017128Molecular functionphospholipid scramblase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0032791Molecular functionlead ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene namePLSCR3
Protein namePhospholipid scramblase
Phospholipid scramblase 3
Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)
Synonyms
DescriptionFUNCTION: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria . Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response . Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis . Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases . Regulates cardiolipin de novo biosynthesis and its resynthesis . .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

AccessionsENST00000576201.5
ENST00000576362.5
Q9NRY6
ENST00000571078.5
I3L1V1
ENST00000571802.1
I3L1P6
I3L161
ENST00000619711.5
ENST00000640375.1
ENST00000639780.1
I3L4F5
I3NI29
I3L3X5
ENST00000573070.5
ENST00000574401.5
ENST00000324822.15
ENST00000573213.1
ENST00000575434.4
ENST00000640053.1
ENST00000639874.2