RRAGA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042593Biological processglucose homeostasis
GO_0009267Biological processcellular response to starvation
GO_0031669Biological processcellular response to nutrient levels
GO_0035556Biological processintracellular signal transduction
GO_0061462Biological processprotein localization to lysosome
GO_0034198Biological processcellular response to amino acid starvation
GO_0071230Biological processcellular response to amino acid stimulus
GO_0010507Biological processnegative regulation of autophagy
GO_0006915Biological processapoptotic process
GO_0008104Biological processprotein localization
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0032008Biological processpositive regulation of TOR signaling
GO_0072657Biological processprotein localization to membrane
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_1990130Cellular componentGATOR1 complex
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_1990131Cellular componentGtr1-Gtr2 GTPase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990877Cellular componentFNIP-folliculin RagC/D GAP
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005525Molecular functionGTP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRRAGA
Protein nameRas-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1)
Synonyms
DescriptionFUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade . Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) . In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB . Involved in the RCC1/Ran-GTPase pathway . May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death . .; FUNCTION: (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. .

AccessionsQ7L523
ENST00000380527.3