TPX2 | OmnibusX

Name	Number of supported studies	Average coverage
B cell	4 studies	18% ± 4%	Explore
erythrocyte	4 studies	30% ± 13%	Explore
CD4-positive, alpha-beta T cell	4 studies	34% ± 7%	Explore
CD8-positive, alpha-beta T cell	4 studies	28% ± 9%	Explore
plasmablast	3 studies	32% ± 13%	Explore
plasma cell	3 studies	23% ± 3%	Explore
T cell	3 studies	23% ± 3%	Explore
hematopoietic precursor cell	3 studies	22% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	24% ± 5%	Explore
transit amplifying cell	3 studies	37% ± 6%	Explore
pro-B cell	3 studies	24% ± 3%	Explore
natural killer cell	3 studies	25% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	23% ± 2%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TPX2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	99%	3361.30	1798 / 1809	96%	93.46	455 / 472
intestine	54%	595.81	517 / 966	97%	118.65	511 / 527
lung	63%	334.50	363 / 578	86%	89.07	988 / 1155
esophagus	43%	773.46	627 / 1445	99%	130.30	181 / 183
stomach	44%	397.21	158 / 359	97%	123.07	278 / 286
breast	41%	130.51	189 / 459	90%	82.17	1009 / 1118
bladder	19%	65.14	4 / 21	95%	109.97	477 / 504
uterus	12%	44.98	21 / 170	98%	148.96	452 / 459
ovary	12%	63.17	21 / 180	98%	103.25	421 / 430
liver	55%	243.44	124 / 226	49%	24.09	199 / 406
lymph node	0%	0	0 / 0	100%	105.59	29 / 29
tonsil	0%	0	0 / 0	100%	172.18	45 / 45
ureter	0%	0	0 / 0	100%	28.02	1 / 1
spleen	96%	886.68	231 / 241	0%	0	0 / 0
brain	36%	83.22	951 / 2642	47%	30.87	334 / 705
adrenal gland	56%	206.65	145 / 258	23%	12.37	52 / 230
pancreas	4%	16.29	14 / 328	71%	35.99	126 / 178
peripheral blood	71%	2712.52	662 / 929	0%	0	0 / 0
adipose	47%	159.81	568 / 1204	0%	0	0 / 0
blood vessel	44%	121.57	585 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	39%	10.25	31 / 80
thymus	21%	61.24	140 / 653	17%	21.19	100 / 605
kidney	18%	108.01	16 / 89	15%	6.60	131 / 901
muscle	32%	76.69	255 / 803	0%	0	0 / 0
prostate	16%	54.21	40 / 245	14%	4.78	71 / 502
heart	13%	47.10	113 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0000278	Biological process	mitotic cell cycle
GO_0051301	Biological process	cell division
GO_0007020	Biological process	microtubule nucleation
GO_0007026	Biological process	negative regulation of microtubule depolymerization
GO_0032147	Biological process	activation of protein kinase activity
GO_0090307	Biological process	mitotic spindle assembly
GO_0006915	Biological process	apoptotic process
GO_0060236	Biological process	regulation of mitotic spindle organization
GO_0005874	Cellular component	microtubule
GO_0000922	Cellular component	spindle pole
GO_0072686	Cellular component	mitotic spindle
GO_0043203	Cellular component	axon hillock
GO_0005654	Cellular component	nucleoplasm
GO_0045171	Cellular component	intercellular bridge
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0060090	Molecular function	molecular adaptor activity
GO_0061676	Molecular function	importin-alpha family protein binding
GO_0019901	Molecular function	protein kinase binding
GO_0005515	Molecular function	protein binding

Gene name	TPX2
Protein name	TPX2 protein Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) HCTP4 (TPX2, microtubule-associated, homolog (Xenopus laevis), isoform CRA_b) (cDNA, FLJ92922)
Synonyms	C20orf2 hCG_38821 HCA519 HCTP4 DIL2 C20orf1
Description	FUNCTION: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules . Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation . TPX2 is inactivated upon binding to importin-alpha . At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation . .
Accessions	ENST00000340513.4 [Q9ULW0-2] ENST00000300403.11 [Q9ULW0-1] Q9ULW0 Q96FC3 Q643R0

TPX2 report