MELK report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MELK at tissue level.

III. Associated gene sets

GO_0008283Biological processcell population proliferation
GO_0030097Biological processhemopoiesis
GO_0061351Biological processneural precursor cell proliferation
GO_0006915Biological processapoptotic process
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0006468Biological processprotein phosphorylation
GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0046777Biological processprotein autophosphorylation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0008289Molecular functionlipid binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMELK
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)
SynonymsKIAA0175
DescriptionFUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. .

AccessionsENST00000543751.5 [Q14680-6]
ENST00000536329.5 [Q14680-5]
A0A0D9SFL8
ENST00000495529.5
ENST00000298048.7 [Q14680-1]
A0A0D9SGI4
Q14680
ENST00000626154.2
ENST00000536987.5 [Q14680-4]
A0A0D9SFF9
ENST00000541717.4 [Q14680-7]
A0A0D9SFB9
ENST00000627766.2
ENST00000536860.5 [Q14680-8]
ENST00000625974.2
ENST00000545008.5 [Q14680-2]