NSG1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
neuron	7 studies	46% ± 25%	Explore
retinal ganglion cell	6 studies	67% ± 30%	Explore
GABAergic neuron	6 studies	36% ± 10%	Explore
ON-bipolar cell	5 studies	37% ± 29%	Explore
mesothelial cell	4 studies	27% ± 14%	Explore
retinal bipolar neuron	4 studies	27% ± 6%	Explore
OFF-bipolar cell	4 studies	56% ± 26%	Explore
basal cell	4 studies	23% ± 4%	Explore
amacrine cell	4 studies	44% ± 20%	Explore
glutamatergic neuron	4 studies	44% ± 18%	Explore
interneuron	4 studies	33% ± 13%	Explore
mucosal invariant T cell	4 studies	17% ± 2%	Explore
GABAergic amacrine cell	3 studies	28% ± 10%	Explore
epithelial cell	3 studies	30% ± 10%	Explore
keratinocyte	3 studies	28% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	24% ± 5%	Explore
eye	5 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	92%	5000.74	166 / 180	88%	43.74	380 / 430
brain	89%	5419.01	2343 / 2642	86%	30.11	605 / 705
skin	72%	4951.85	1298 / 1809	88%	180.25	414 / 472
adrenal gland	24%	526.52	61 / 258	77%	84.65	177 / 230
eye	0%	0	0 / 0	100%	175.28	80 / 80
esophagus	37%	700.24	537 / 1445	49%	7.69	90 / 183
prostate	39%	745.74	95 / 245	46%	7.45	231 / 502
uterus	29%	328.17	49 / 170	45%	11.39	206 / 459
bladder	33%	621.00	7 / 21	38%	12.40	192 / 504
tonsil	0%	0	0 / 0	49%	7.58	22 / 45
intestine	19%	196.65	181 / 966	13%	1.22	71 / 527
kidney	18%	221.33	16 / 89	8%	2.13	73 / 901
lung	1%	5.77	3 / 578	24%	4.63	277 / 1155
stomach	9%	92.30	34 / 359	15%	1.55	42 / 286
breast	11%	102.24	50 / 459	8%	1.30	87 / 1118
pancreas	0%	0	0 / 328	18%	3.38	32 / 178
thymus	0%	2.24	1 / 653	18%	3.88	107 / 605
adipose	11%	135.39	128 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	10%	0.87	3 / 29
heart	10%	106.62	82 / 861	0%	0	0 / 0
peripheral blood	9%	154.07	81 / 929	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0.06	1 / 406
blood vessel	0%	3.42	2 / 1335	0%	0	0 / 0
muscle	0%	0.96	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001921	Biological process	positive regulation of receptor recycling
GO_1900271	Biological process	regulation of long-term synaptic potentiation
GO_0099627	Biological process	neurotransmitter receptor cycle
GO_0098814	Biological process	spontaneous synaptic transmission
GO_0048268	Biological process	clathrin coat assembly
GO_0016197	Biological process	endosomal transport
GO_0098887	Biological process	neurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0099630	Biological process	postsynaptic neurotransmitter receptor cycle
GO_0006915	Biological process	apoptotic process
GO_0099003	Biological process	vesicle-mediated transport in synapse
GO_0042982	Biological process	amyloid precursor protein metabolic process
GO_0007212	Biological process	G protein-coupled dopamine receptor signaling pathway
GO_0001881	Biological process	receptor recycling
GO_0098978	Cellular component	glutamatergic synapse
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0036477	Cellular component	somatodendritic compartment
GO_0031901	Cellular component	early endosome membrane
GO_0055038	Cellular component	recycling endosome membrane
GO_0030425	Cellular component	dendrite
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016328	Cellular component	lateral plasma membrane
GO_0005770	Cellular component	late endosome
GO_0005737	Cellular component	cytoplasm
GO_0045211	Cellular component	postsynaptic membrane
GO_0098845	Cellular component	postsynaptic endosome
GO_0043202	Cellular component	lysosomal lumen
GO_0005768	Cellular component	endosome
GO_0032580	Cellular component	Golgi cisterna membrane
GO_0032585	Cellular component	multivesicular body membrane
GO_0005634	Cellular component	nucleus
GO_0032051	Molecular function	clathrin light chain binding
GO_0035255	Molecular function	ionotropic glutamate receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NSG1
Protein name	Neuronal vesicle trafficking-associated protein 1 (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1)
Synonyms	D4S234 NEEP21
Description	FUNCTION: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage . .
Accessions	ENST00000504171.1 [P42857-2] ENST00000433139.6 [P42857-1] P42857 ENST00000621129.5 [P42857-1] ENST00000421177.6 [P42857-1] ENST00000397958.5 [P42857-1] ENST00000513829.5 [P42857-1] ENST00000506380.5 [P42857-1] ENST00000505246.5 [P42857-1] ENST00000513555.5 [P42857-1]

NSG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review