ESPL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ESPL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ESPL1 at tissue level.

III. Associated gene sets

GO_0045842Biological processpositive regulation of mitotic metaphase/anaphase transition
GO_0000070Biological processmitotic sister chromatid segregation
GO_0045143Biological processhomologous chromosome segregation
GO_0051307Biological processmeiotic chromosome separation
GO_0000281Biological processmitotic cytokinesis
GO_0040001Biological processestablishment of mitotic spindle localization
GO_0000212Biological processmeiotic spindle organization
GO_0045875Biological processnegative regulation of sister chromatid cohesion
GO_0006508Biological processproteolysis
GO_0006915Biological processapoptotic process
GO_0051306Biological processmitotic sister chromatid separation
GO_0072686Cellular componentmitotic spindle
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003824Molecular functioncatalytic activity
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameESPL1
Protein nameSeparin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase)
Extra spindle pole bodies like 1, separase
SynonymsESP1
KIAA0165
DescriptionFUNCTION: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. .

AccessionsH3BM31
ENST00000553219.6
Q14674
ENST00000552671.5
H3BRX7
ENST00000257934.9 [Q14674-1]