ASAH2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ASAH2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASAH2 at tissue level.

III. Associated gene sets

GO_0006670Biological processsphingosine metabolic process
GO_0044241Biological processlipid digestion
GO_0006672Biological processceramide metabolic process
GO_0046514Biological processceramide catabolic process
GO_0046513Biological processceramide biosynthetic process
GO_0071345Biological processcellular response to cytokine stimulus
GO_0007346Biological processregulation of mitotic cell cycle
GO_0046512Biological processsphingosine biosynthetic process
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0006915Biological processapoptotic process
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005901Cellular componentcaveola
GO_0017040Molecular functionN-acylsphingosine amidohydrolase activity
GO_0102121Molecular functionceramidase activity
GO_0008270Molecular functionzinc ion binding
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameASAH2
Protein nameNeutral ceramidase (EC 3.5.1.23)
Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form]
N-acylsphingosine amidohydrolase 2
SynonymsHNAC1
DescriptionFUNCTION: Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine . Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells . Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity). .

AccessionsA0A0C4DFQ8
V9GY52
ENST00000474434.2
ENST00000489640.5
ENST00000682911.1 [Q9NR71-1]
Q9NR71
ENST00000395526.9 [Q9NR71-1]
ENST00000329428.10
ENST00000443575.5
E9PBM9
V9GYJ5