MCM2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MCM2 at tissue level.

III. Associated gene sets

GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0071353Biological processcellular response to interleukin-4
GO_0006260Biological processDNA replication
GO_0006334Biological processnucleosome assembly
GO_0000727Biological processdouble-strand break repair via break-induced replication
GO_0090102Biological processcochlea development
GO_0006270Biological processDNA replication initiation
GO_0030174Biological processregulation of DNA-templated DNA replication initiation
GO_0006915Biological processapoptotic process
GO_1902975Biological processmitotic DNA replication initiation
GO_0005730Cellular componentnucleolus
GO_0005664Cellular componentnuclear origin of replication recognition complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0042555Cellular componentMCM complex
GO_0071162Cellular componentCMG complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0042393Molecular functionhistone binding
GO_0003688Molecular functionDNA replication origin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0017116Molecular functionsingle-stranded DNA helicase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0043138Molecular function3'-5' DNA helicase activity

IV. Literature review

[source]
Gene nameMCM2
Protein nameDNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
DNA replication licensing factor MCM2 (EC 3.6.4.12)
Minichromosome maintenance complex component 2
DNA helicase (EC 3.6.4.12)
SynonymsKIAA0030
BM28
CCNL1
CDCL1
DescriptionFUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity . Required for the entry in S phase and for cell division . Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis . .

AccessionsC9J013
ENST00000474964.5
C9JZ21
ENST00000491422.1
H7C4N9
ENST00000265056.12
ENST00000480910.1
ENST00000477668.5
ENST00000472731.1
H0Y8E6
F8WDM3
P49736
Q9BWF4