MEF2D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001649Biological processosteoblast differentiation
GO_0002062Biological processchondrocyte differentiation
GO_0001958Biological processendochondral ossification
GO_0030154Biological processcell differentiation
GO_0007512Biological processadult heart development
GO_0007517Biological processmuscle organ development
GO_0006915Biological processapoptotic process
GO_0035914Biological processskeletal muscle cell differentiation
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMEF2D
Protein nameMyocyte enhancer factor 2D
Myocyte-specific enhancer factor 2D
MEF2D variant protein
MEF2D protein (Myocyte enhancer factor 2D)
Synonymsprotein
variant
DescriptionFUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). .

AccessionsQ4LE66
ENST00000475587.2
A0A0G2JLL8
ENST00000348159.9 [Q14814-1]
ENST00000464356.6 [Q14814-5]
ENST00000708597.1 [Q14814-4]
Q05BX2
Q14814
ENST00000708596.1 [Q14814-1]
ENST00000489057.1
ENST00000360595.7 [Q14814-4]
ENST00000708595.1 [Q14814-5]