Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasma cell | 32 studies | 81% ± 21% | |
B cell | 26 studies | 34% ± 21% | |
plasmacytoid dendritic cell | 26 studies | 75% ± 15% | |
plasmablast | 12 studies | 85% ± 18% | |
naive B cell | 12 studies | 25% ± 10% | |
IgG plasma cell | 10 studies | 87% ± 9% | |
IgA plasma cell | 9 studies | 87% ± 9% | |
immature B cell | 7 studies | 54% ± 21% | |
memory B cell | 6 studies | 20% ± 3% | |
precursor B cell | 6 studies | 70% ± 15% | |
pro-B cell | 5 studies | 67% ± 15% | |
hematopoietic precursor cell | 4 studies | 40% ± 21% | |
IgM plasma cell | 4 studies | 84% ± 15% | |
regulatory T cell | 4 studies | 22% ± 4% | |
germinal center B cell | 3 studies | 31% ± 1% | |
gamma-delta T cell | 3 studies | 41% ± 23% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
intestine | 3 studies | 31% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 93% | 643.05 | 537 / 578 | 81% | 55.86 | 936 / 1155 |
prostate | 79% | 296.32 | 194 / 245 | 80% | 24.27 | 404 / 502 |
stomach | 73% | 637.78 | 262 / 359 | 61% | 24.13 | 175 / 286 |
breast | 56% | 309.07 | 255 / 459 | 75% | 37.58 | 842 / 1118 |
intestine | 56% | 1213.59 | 537 / 966 | 58% | 20.58 | 308 / 527 |
lymph node | 0% | 0 | 0 / 0 | 100% | 333.30 | 29 / 29 |
spleen | 100% | 10287.62 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 2633.93 | 861 / 929 | 0% | 0 | 0 / 0 |
bladder | 33% | 232.05 | 7 / 21 | 50% | 21.17 | 250 / 504 |
tonsil | 0% | 0 | 0 / 0 | 82% | 74.67 | 37 / 45 |
uterus | 25% | 59.03 | 43 / 170 | 50% | 26.38 | 228 / 459 |
liver | 54% | 121.95 | 121 / 226 | 18% | 6.80 | 72 / 406 |
thymus | 31% | 420.28 | 205 / 653 | 38% | 106.88 | 232 / 605 |
kidney | 43% | 252.29 | 38 / 89 | 21% | 8.55 | 191 / 901 |
esophagus | 23% | 91.59 | 327 / 1445 | 39% | 14.75 | 71 / 183 |
pancreas | 5% | 12.38 | 18 / 328 | 56% | 19.93 | 99 / 178 |
skin | 3% | 3.89 | 47 / 1809 | 49% | 34.18 | 231 / 472 |
ovary | 18% | 30.70 | 32 / 180 | 30% | 8.90 | 127 / 430 |
adipose | 20% | 79.18 | 244 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 10% | 35.35 | 26 / 258 | 7% | 2.21 | 15 / 230 |
blood vessel | 14% | 59.40 | 185 / 1335 | 0% | 0 | 0 / 0 |
heart | 4% | 9.39 | 38 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 4% | 4.32 | 3 / 80 |
brain | 0% | 0.79 | 11 / 2642 | 1% | 0.77 | 8 / 705 |
muscle | 1% | 1.01 | 6 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006915 | Biological process | apoptotic process |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0033622 | Biological process | integrin activation |
GO_0002639 | Biological process | positive regulation of immunoglobulin production |
GO_0046626 | Biological process | regulation of insulin receptor signaling pathway |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0030888 | Biological process | regulation of B cell proliferation |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0005576 | Cellular component | extracellular region |
GO_0034663 | Cellular component | endoplasmic reticulum chaperone complex |
GO_0005515 | Molecular function | protein binding |
Gene name | MZB1 |
Protein name | Marginal zone B- and B1-cell-specific protein (Mesenteric estrogen-dependent adipose 7) (MEDA-7) (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein) Marginal zone B and B1 cell specific protein |
Synonyms | HSPC190 PACAP MEDA7 |
Description | FUNCTION: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. .; FUNCTION: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. |
Accessions | ENST00000503481.5 [Q8WU39-2] H0Y9L3 ENST00000503351.1 Q8WU39 ENST00000513389.1 ENST00000417694.6 [Q8WU39-4] ENST00000302125.9 [Q8WU39-1] D6RII0 |