MZB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0033622Biological processintegrin activation
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0046626Biological processregulation of insulin receptor signaling pathway
GO_0042127Biological processregulation of cell population proliferation
GO_0030888Biological processregulation of B cell proliferation
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005576Cellular componentextracellular region
GO_0034663Cellular componentendoplasmic reticulum chaperone complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMZB1
Protein nameMarginal zone B- and B1-cell-specific protein (Mesenteric estrogen-dependent adipose 7) (MEDA-7) (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein)
Marginal zone B and B1 cell specific protein
SynonymsHSPC190
PACAP
MEDA7
DescriptionFUNCTION: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. .; FUNCTION: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

AccessionsENST00000503481.5 [Q8WU39-2]
H0Y9L3
ENST00000503351.1
Q8WU39
ENST00000513389.1
ENST00000417694.6 [Q8WU39-4]
ENST00000302125.9 [Q8WU39-1]
D6RII0