IER3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	34 studies	50% ± 22%	Explore
fibroblast	29 studies	45% ± 21%	Explore
endothelial cell	26 studies	37% ± 15%	Explore
classical monocyte	25 studies	44% ± 23%	Explore
conventional dendritic cell	24 studies	35% ± 15%	Explore
basal cell	21 studies	50% ± 14%	Explore
dendritic cell	19 studies	39% ± 20%	Explore
smooth muscle cell	19 studies	40% ± 16%	Explore
monocyte	18 studies	50% ± 18%	Explore
epithelial cell	18 studies	40% ± 19%	Explore
mast cell	16 studies	31% ± 17%	Explore
pericyte	16 studies	48% ± 19%	Explore
non-classical monocyte	12 studies	39% ± 21%	Explore
endothelial cell of vascular tree	12 studies	45% ± 20%	Explore
neutrophil	11 studies	47% ± 17%	Explore
myeloid cell	11 studies	49% ± 21%	Explore
secretory cell	10 studies	48% ± 16%	Explore
connective tissue cell	10 studies	35% ± 19%	Explore
vein endothelial cell	10 studies	32% ± 16%	Explore
natural killer cell	9 studies	24% ± 7%	Explore
goblet cell	9 studies	39% ± 18%	Explore
myofibroblast cell	8 studies	35% ± 13%	Explore
ciliated cell	8 studies	39% ± 26%	Explore
endothelial cell of artery	7 studies	30% ± 13%	Explore
leukocyte	7 studies	33% ± 15%	Explore
endothelial cell of lymphatic vessel	6 studies	42% ± 18%	Explore
mononuclear phagocyte	6 studies	45% ± 11%	Explore
T cell	5 studies	25% ± 7%	Explore
type I pneumocyte	5 studies	31% ± 16%	Explore
club cell	5 studies	33% ± 20%	Explore
respiratory goblet cell	5 studies	24% ± 6%	Explore
abnormal cell	5 studies	39% ± 13%	Explore
mesothelial cell	5 studies	42% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	25% ± 10%	Explore
type II pneumocyte	4 studies	28% ± 17%	Explore
squamous epithelial cell	4 studies	41% ± 15%	Explore
monocyte-derived dendritic cell	4 studies	71% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	35% ± 9%	Explore
transit amplifying cell	4 studies	33% ± 9%	Explore
kidney loop of Henle epithelial cell	4 studies	37% ± 12%	Explore
renal principal cell	4 studies	51% ± 26%	Explore
microglial cell	4 studies	42% ± 27%	Explore
intermediate monocyte	4 studies	52% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	75% ± 4%	Explore
keratinocyte	4 studies	47% ± 22%	Explore
pancreatic A cell	3 studies	39% ± 22%	Explore
type B pancreatic cell	3 studies	52% ± 29%	Explore
progenitor cell	3 studies	32% ± 10%	Explore
CD4-positive, alpha-beta T cell	3 studies	26% ± 3%	Explore
renal alpha-intercalated cell	3 studies	29% ± 7%	Explore
adventitial cell	3 studies	36% ± 1%	Explore
tissue-resident macrophage	3 studies	52% ± 20%	Explore
inflammatory macrophage	3 studies	48% ± 22%	Explore
capillary endothelial cell	3 studies	26% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	36% ± 8%	Explore
pancreatic ductal cell	3 studies	77% ± 5%	Explore
intestinal crypt stem cell	3 studies	32% ± 13%	Explore
glial cell	3 studies	23% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	48% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	30% ± 14%	Explore
peripheral blood	6 studies	23% ± 6%	Explore
intestine	6 studies	32% ± 11%	Explore
uterus	6 studies	45% ± 16%	Explore
kidney	5 studies	27% ± 12%	Explore
pancreas	4 studies	45% ± 21%	Explore
prostate	4 studies	46% ± 16%	Explore
breast	4 studies	49% ± 9%	Explore
esophagus	3 studies	47% ± 4%	Explore
skin	3 studies	55% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	99%	4405.44	356 / 359	98%	193.28	279 / 286
intestine	95%	2324.81	919 / 966	98%	209.88	518 / 527
lung	97%	5504.62	563 / 578	90%	97.98	1037 / 1155
pancreas	95%	2129.51	313 / 328	92%	119.34	163 / 178
esophagus	84%	3546.99	1211 / 1445	98%	130.58	179 / 183
skin	98%	2795.32	1766 / 1809	79%	102.28	372 / 472
uterus	85%	1354.11	145 / 170	85%	103.99	389 / 459
bladder	81%	1895.43	17 / 21	84%	108.16	423 / 504
kidney	100%	4961.92	89 / 89	65%	47.48	583 / 901
breast	74%	1861.18	339 / 459	90%	116.44	1010 / 1118
ovary	61%	1072.42	110 / 180	88%	80.62	379 / 430
thymus	75%	1190.89	488 / 653	64%	38.04	389 / 605
prostate	96%	2204.59	234 / 245	34%	16.43	170 / 502
adrenal gland	94%	3240.38	242 / 258	21%	14.47	49 / 230
liver	69%	1911.17	155 / 226	45%	32.80	184 / 406
spleen	99%	2467.46	239 / 241	0%	0	0 / 0
peripheral blood	92%	1877.74	853 / 929	0%	0	0 / 0
blood vessel	91%	3060.51	1214 / 1335	0%	0	0 / 0
heart	85%	3028.85	728 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	62.94	38 / 45
adipose	77%	3608.54	931 / 1204	0%	0	0 / 0
brain	20%	211.17	534 / 2642	14%	6.23	101 / 705
lymph node	0%	0	0 / 0	34%	14.31	10 / 29
eye	0%	0	0 / 0	19%	8.09	15 / 80
muscle	12%	124.52	94 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_2000377	Biological process	regulation of reactive oxygen species metabolic process
GO_0006096	Biological process	glycolytic process
GO_0006282	Biological process	regulation of DNA repair
GO_0006974	Biological process	DNA damage response
GO_0001562	Biological process	response to protozoan
GO_1901029	Biological process	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0045820	Biological process	negative regulation of glycolytic process
GO_0046822	Biological process	regulation of nucleocytoplasmic transport
GO_0003085	Biological process	negative regulation of systemic arterial blood pressure
GO_0007095	Biological process	mitotic G2 DNA damage checkpoint signaling
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0008630	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0006915	Biological process	apoptotic process
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IER3
Protein name	Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1) Immediate early response 3 (Radiation-inducible immediate-early gene IEX-1) IER3 (Immediate early response 3) (Radiation-inducible immediate early response gene IEX1)
Synonyms	hCG_26002 IEX1 DIF2 PRG1
Description	FUNCTION: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. .
Accessions	ENST00000450236.2 ENST00000383560.4 ENST00000376377.2 ENST00000400509.1 ENST00000416336.1 ENST00000439190.2 ENST00000435856.2 ENST00000416884.2 P46695 ENST00000436988.1 Q5ST79 Q5ST77 ENST00000259874.6 ENST00000429592.1 ENST00000446599.1

IER3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review