PLK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090166Biological processGolgi disassembly
GO_0031122Biological processcytoplasmic microtubule organization
GO_0007113Biological processendomitotic cell cycle
GO_2000777Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO_0007052Biological processmitotic spindle organization
GO_0009314Biological processresponse to radiation
GO_0044819Biological processmitotic G1/S transition checkpoint signaling
GO_0006974Biological processDNA damage response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006970Biological processresponse to osmotic stress
GO_0051302Biological processregulation of cell division
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1904716Biological processpositive regulation of chaperone-mediated autophagy
GO_0043066Biological processnegative regulation of apoptotic process
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0000302Biological processresponse to reactive oxygen species
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0006915Biological processapoptotic process
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0006468Biological processprotein phosphorylation
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0032465Biological processregulation of cytokinesis
GO_0005795Cellular componentGolgi stack
GO_0005730Cellular componentnucleolus
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0002039Molecular functionp53 binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLK3
Protein nameSerine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)
SynonymsCNK
FNK
PRK
DescriptionFUNCTION: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. .

AccessionsENST00000372201.5
Q9H4B4