BIRC5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
T cell	6 studies	28% ± 10%	Explore
B cell	5 studies	26% ± 4%	Explore
plasmablast	5 studies	42% ± 14%	Explore
epithelial cell	5 studies	26% ± 12%	Explore
transit amplifying cell	4 studies	30% ± 1%	Explore
plasma cell	4 studies	26% ± 7%	Explore
erythrocyte	4 studies	33% ± 13%	Explore
CD4-positive, alpha-beta T cell	4 studies	41% ± 7%	Explore
CD8-positive, alpha-beta T cell	4 studies	31% ± 11%	Explore
erythroblast	3 studies	43% ± 23%	Explore
pro-B cell	3 studies	27% ± 5%	Explore
natural killer cell	3 studies	27% ± 1%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BIRC5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	93%	1670.15	1677 / 1809	95%	49.94	449 / 472
lung	68%	250.90	394 / 578	87%	54.97	1009 / 1155
intestine	53%	372.72	515 / 966	95%	57.74	500 / 527
stomach	48%	293.13	172 / 359	95%	44.64	271 / 286
esophagus	44%	552.98	636 / 1445	93%	39.81	170 / 183
bladder	19%	36.86	4 / 21	94%	62.90	476 / 504
breast	25%	60.28	116 / 459	88%	46.03	983 / 1118
uterus	10%	24.02	17 / 170	99%	80.29	454 / 459
ovary	8%	35.43	15 / 180	95%	46.65	409 / 430
liver	45%	132.18	102 / 226	57%	18.76	231 / 406
lymph node	0%	0	0 / 0	100%	75.08	29 / 29
tonsil	0%	0	0 / 0	100%	82.43	45 / 45
ureter	0%	0	0 / 0	100%	36.71	1 / 1
spleen	98%	734.15	235 / 241	0%	0	0 / 0
pancreas	10%	18.62	33 / 328	69%	19.89	122 / 178
peripheral blood	74%	1385.60	685 / 929	0%	0	0 / 0
adrenal gland	46%	117.90	119 / 258	16%	5.71	37 / 230
brain	6%	8.58	152 / 2642	46%	24.74	325 / 705
prostate	29%	54.86	70 / 245	21%	4.38	103 / 502
kidney	22%	81.75	20 / 89	13%	3.16	117 / 901
thymus	16%	30.49	107 / 653	15%	14.15	92 / 605
eye	0%	0	0 / 0	29%	3.89	23 / 80
adipose	25%	67.73	301 / 1204	0%	0	0 / 0
blood vessel	15%	29.35	201 / 1335	0%	0	0 / 0
heart	9%	24.60	77 / 861	0%	0	0 / 0
muscle	1%	1.12	7 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007605	Biological process	sensory perception of sound
GO_0000278	Biological process	mitotic cell cycle
GO_1901970	Biological process	positive regulation of mitotic sister chromatid separation
GO_0000281	Biological process	mitotic cytokinesis
GO_0090307	Biological process	mitotic spindle assembly
GO_0051256	Biological process	mitotic spindle midzone assembly
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0090267	Biological process	positive regulation of mitotic cell cycle spindle assembly checkpoint
GO_0006915	Biological process	apoptotic process
GO_1902425	Biological process	positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_1903490	Biological process	positive regulation of mitotic cytokinesis
GO_0006468	Biological process	protein phosphorylation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0031503	Biological process	protein-containing complex localization
GO_0000775	Cellular component	chromosome, centromeric region
GO_1990713	Cellular component	survivin complex
GO_0030496	Cellular component	midbody
GO_0005874	Cellular component	microtubule
GO_0000228	Cellular component	nuclear chromosome
GO_0000776	Cellular component	kinetochore
GO_0005654	Cellular component	nucleoplasm
GO_0032133	Cellular component	chromosome passenger complex
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0004869	Molecular function	cysteine-type endopeptidase inhibitor activity
GO_0019899	Molecular function	enzyme binding
GO_0042802	Molecular function	identical protein binding
GO_0031267	Molecular function	small GTPase binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0008017	Molecular function	microtubule binding
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	BIRC5
Protein name	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Synonyms	IAP4 API4
Description	FUNCTION: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis . Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis . Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules . Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis . The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules . May counteract a default induction of apoptosis in G2/M phase . The acetylated form represses STAT3 transactivation of target gene promoters . May play a role in neoplasia . Inhibitor of CASP3 and CASP7 . Essential for the maintenance of mitochondrial integrity and function . Isoform 2 and isoform 3 do not appear to play vital roles in mitosis . Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform . .
Accessions	A3E0Z6 A3E0Z4 E7CU85 K7ELG2 K7EP76 A0A0B4J1S3 A3E0Z5 A0A7L8XZM3 ENST00000587746.5 ENST00000590925.6 [O15392-4] ENST00000591800.1 A3E0Z7 ENST00000374948.6 [O15392-3] ENST00000350051.8 ENST00000590449.1 [O15392-7] H3BLT4 ENST00000301633.8 O15392 ENST00000586192.5 A3E0Z8 ENST00000592734.5 [O15392-6] K7EMW2

BIRC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review