CASP5 | OmnibusX

Name	Number of supported studies	Average coverage
non-classical monocyte	3 studies	17% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CASP5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	71%	290.70	690 / 966	84%	10.44	443 / 527
lung	99%	73.50	571 / 578	41%	1.20	472 / 1155
spleen	100%	160.70	241 / 241	0%	0	0 / 0
stomach	22%	6.54	78 / 359	78%	7.35	223 / 286
peripheral blood	83%	460.99	768 / 929	0%	0	0 / 0
bladder	29%	14.52	6 / 21	37%	2.82	187 / 504
lymph node	0%	0	0 / 0	62%	5.11	18 / 29
esophagus	15%	3.01	215 / 1445	45%	2.69	82 / 183
kidney	30%	5.30	27 / 89	20%	0.40	177 / 901
adipose	42%	10.43	511 / 1204	0%	0	0 / 0
prostate	41%	8.69	101 / 245	0%	0.00	2 / 502
brain	15%	3.20	388 / 2642	25%	0.52	173 / 705
breast	28%	8.14	130 / 459	10%	0.23	115 / 1118
adrenal gland	32%	5.16	83 / 258	3%	0.08	8 / 230
liver	31%	4.95	70 / 226	3%	0.11	14 / 406
uterus	15%	2.76	26 / 170	19%	0.49	87 / 459
skin	13%	2.14	229 / 1809	21%	0.50	97 / 472
pancreas	7%	0.94	23 / 328	24%	0.46	43 / 178
tonsil	0%	0	0 / 0	29%	0.63	13 / 45
blood vessel	21%	4.87	285 / 1335	0%	0	0 / 0
ovary	11%	1.91	20 / 180	6%	0.09	27 / 430
thymus	16%	2.91	102 / 653	2%	0.02	10 / 605
heart	16%	3.23	141 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.05	3 / 80
muscle	1%	0.14	9 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006915	Biological process	apoptotic process
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0021762	Biological process	substantia nigra development
GO_0006508	Biological process	proteolysis
GO_0043525	Biological process	positive regulation of neuron apoptotic process
GO_0051604	Biological process	protein maturation
GO_0072558	Cellular component	NLRP1 inflammasome complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0097153	Molecular function	cysteine-type endopeptidase activity involved in apoptotic process
GO_0008234	Molecular function	cysteine-type peptidase activity
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding

Gene name	CASP5
Protein name	Caspase 5 Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10]
Synonyms	ICH3
Description	FUNCTION: Thiol protease that acts as a mediator of programmed cell death . Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis . Also mediates cleavage and maturation of IL18 . Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 . During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation . .
Accessions	ENST00000438448.6 P51878 ENST00000531367.5 [P51878-3] ENST00000456200.5 [P51878-4] ENST00000456094.1 ENST00000444749.6 [P51878-2] H7C0P5 ENST00000526056.5 [P51878-5] C9JF14 ENST00000393141.6 [P51878-5] ENST00000418434.5 [P51878-3] ENST00000260315.8 [P51878-1]

CASP5 report