BIRC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_2000116Biological processregulation of cysteine-type endopeptidase activity
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0060544Biological processregulation of necroptotic process
GO_0050727Biological processregulation of inflammatory response
GO_0045088Biological processregulation of innate immune response
GO_0039535Biological processregulation of RIG-I signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0060546Biological processnegative regulation of necroptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0070424Biological processregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_0006915Biological processapoptotic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0034121Biological processregulation of toll-like receptor signaling pathway
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0051726Biological processregulation of cell cycle
GO_0007166Biological processcell surface receptor signaling pathway
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0043027Molecular functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0044877Molecular functionprotein-containing complex binding
GO_0016740Molecular functiontransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBIRC3
Protein nameAlternative protein BIRC3
Baculoviral IAP repeat containing 3
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
SynonymsRNF49
API2
MIHC
DescriptionFUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. .

AccessionsQ13489
H0YCJ5
ENST00000673846.1
ENST00000527309.2
ENST00000263464.9
ENST00000532808.5
L8E7L9
ENST00000526421.6
A0A669KBC7