PDCD4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	34% ± 12%	Explore
B cell	33 studies	34% ± 10%	Explore
CD8-positive, alpha-beta T cell	32 studies	38% ± 11%	Explore
T cell	31 studies	33% ± 11%	Explore
endothelial cell	29 studies	29% ± 11%	Explore
CD4-positive, alpha-beta T cell	29 studies	40% ± 12%	Explore
mature NK T cell	21 studies	37% ± 14%	Explore
mast cell	20 studies	30% ± 12%	Explore
regulatory T cell	20 studies	32% ± 9%	Explore
naive B cell	19 studies	32% ± 8%	Explore
memory B cell	18 studies	34% ± 7%	Explore
basal cell	17 studies	31% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	38% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	42% ± 14%	Explore
mucosal invariant T cell	16 studies	49% ± 13%	Explore
macrophage	16 studies	24% ± 8%	Explore
gamma-delta T cell	16 studies	47% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	30% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	41% ± 13%	Explore
plasmacytoid dendritic cell	13 studies	35% ± 11%	Explore
fibroblast	13 studies	24% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	34% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	45% ± 14%	Explore
endothelial cell of artery	12 studies	31% ± 12%	Explore
ciliated cell	12 studies	31% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	45% ± 15%	Explore
epithelial cell	11 studies	44% ± 22%	Explore
endothelial cell of vascular tree	10 studies	23% ± 7%	Explore
retinal rod cell	9 studies	42% ± 17%	Explore
smooth muscle cell	9 studies	20% ± 4%	Explore
club cell	9 studies	26% ± 11%	Explore
leukocyte	8 studies	40% ± 14%	Explore
microglial cell	8 studies	29% ± 16%	Explore
pericyte	8 studies	18% ± 4%	Explore
plasma cell	8 studies	26% ± 8%	Explore
endothelial cell of lymphatic vessel	7 studies	19% ± 4%	Explore
secretory cell	7 studies	26% ± 9%	Explore
conventional dendritic cell	7 studies	26% ± 10%	Explore
goblet cell	7 studies	36% ± 22%	Explore
T follicular helper cell	7 studies	34% ± 10%	Explore
respiratory goblet cell	6 studies	30% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	33% ± 12%	Explore
non-classical monocyte	6 studies	30% ± 11%	Explore
connective tissue cell	6 studies	23% ± 4%	Explore
enterocyte	6 studies	25% ± 8%	Explore
mesothelial cell	6 studies	26% ± 11%	Explore
progenitor cell	6 studies	24% ± 6%	Explore
adipocyte	6 studies	21% ± 6%	Explore
myeloid cell	6 studies	22% ± 7%	Explore
innate lymphoid cell	6 studies	37% ± 10%	Explore
oligodendrocyte	6 studies	27% ± 6%	Explore
monocyte	6 studies	21% ± 3%	Explore
exhausted T cell	5 studies	37% ± 12%	Explore
classical monocyte	5 studies	25% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	34% ± 10%	Explore
retinal bipolar neuron	5 studies	24% ± 8%	Explore
hematopoietic stem cell	5 studies	26% ± 7%	Explore
lymphocyte	5 studies	43% ± 22%	Explore
precursor B cell	5 studies	29% ± 2%	Explore
capillary endothelial cell	5 studies	23% ± 5%	Explore
astrocyte	5 studies	27% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	46% ± 13%	Explore
GABAergic neuron	5 studies	37% ± 16%	Explore
dendritic cell	5 studies	31% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	31% ± 4%	Explore
hematopoietic precursor cell	4 studies	33% ± 16%	Explore
intestinal crypt stem cell	4 studies	24% ± 8%	Explore
transit amplifying cell	4 studies	39% ± 29%	Explore
erythroblast	4 studies	46% ± 18%	Explore
T-helper 17 cell	4 studies	50% ± 12%	Explore
immature B cell	4 studies	35% ± 7%	Explore
CD4-positive helper T cell	4 studies	47% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 9%	Explore
vein endothelial cell	4 studies	23% ± 6%	Explore
granulocyte	4 studies	37% ± 18%	Explore
brush cell	4 studies	24% ± 2%	Explore
erythrocyte	4 studies	33% ± 12%	Explore
keratinocyte	4 studies	30% ± 4%	Explore
interneuron	4 studies	38% ± 22%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	43% ± 7%	Explore
platelet	3 studies	18% ± 3%	Explore
mononuclear phagocyte	3 studies	23% ± 11%	Explore
plasmablast	3 studies	34% ± 6%	Explore
placental villous trophoblast	3 studies	61% ± 9%	Explore
squamous epithelial cell	3 studies	32% ± 21%	Explore
retinal cone cell	3 studies	25% ± 6%	Explore
duct epithelial cell	3 studies	30% ± 20%	Explore
mucus secreting cell	3 studies	45% ± 16%	Explore
serous secreting cell	3 studies	50% ± 16%	Explore
intraepithelial lymphocyte	3 studies	36% ± 16%	Explore
rod bipolar cell	3 studies	48% ± 15%	Explore
acinar cell	3 studies	54% ± 21%	Explore
IgA plasma cell	3 studies	22% ± 3%	Explore
glutamatergic neuron	3 studies	54% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	27% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	55% ± 23%	Explore
myofibroblast cell	3 studies	25% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 6%	Explore
neuron	3 studies	29% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 4%	Explore
double negative thymocyte	3 studies	39% ± 2%	Explore
myoepithelial cell	3 studies	23% ± 2%	Explore
progenitor cell of mammary luminal epithelium	3 studies	38% ± 6%	Explore
abnormal cell	3 studies	34% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	31% ± 8%	Explore
lung	11 studies	25% ± 7%	Explore
intestine	9 studies	26% ± 7%	Explore
eye	8 studies	36% ± 14%	Explore
brain	7 studies	33% ± 14%	Explore
breast	5 studies	24% ± 3%	Explore
liver	5 studies	35% ± 8%	Explore
placenta	4 studies	29% ± 12%	Explore
bone marrow	4 studies	27% ± 7%	Explore
uterus	4 studies	32% ± 5%	Explore
pancreas	3 studies	39% ± 14%	Explore
thymus	3 studies	26% ± 10%	Explore
adipose	3 studies	23% ± 3%	Explore
skin	3 studies	22% ± 5%	Explore
lymph node	3 studies	34% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	12241.07	653 / 653	100%	218.82	605 / 605
breast	100%	9798.52	459 / 459	100%	210.08	1114 / 1118
prostate	100%	5974.24	244 / 245	100%	113.07	501 / 502
pancreas	100%	34162.12	328 / 328	99%	58.90	176 / 178
uterus	100%	7199.41	170 / 170	95%	57.01	434 / 459
intestine	100%	10602.79	965 / 966	94%	55.04	494 / 527
bladder	100%	5127.43	21 / 21	92%	49.78	466 / 504
stomach	99%	9471.72	357 / 359	91%	47.84	261 / 286
skin	99%	14312.67	1784 / 1809	92%	66.97	432 / 472
ovary	100%	10317.97	180 / 180	89%	41.48	384 / 430
lung	96%	3560.35	553 / 578	93%	43.75	1077 / 1155
esophagus	99%	7840.30	1432 / 1445	89%	43.15	163 / 183
adrenal gland	80%	2446.19	207 / 258	94%	76.56	217 / 230
brain	59%	1426.61	1552 / 2642	91%	36.08	640 / 705
kidney	49%	1326.82	44 / 89	86%	38.01	775 / 901
liver	59%	1554.01	134 / 226	56%	21.61	227 / 406
spleen	100%	7305.07	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	63.63	45 / 45
ureter	0%	0	0 / 0	100%	18.59	1 / 1
adipose	100%	6172.78	1202 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	109.95	79 / 80
lymph node	0%	0	0 / 0	93%	85.34	27 / 29
blood vessel	92%	2953.06	1228 / 1335	0%	0	0 / 0
peripheral blood	68%	4828.47	636 / 929	0%	0	0 / 0
heart	54%	1368.98	469 / 861	0%	0	0 / 0
muscle	5%	108.45	42 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1905461	Biological process	positive regulation of vascular associated smooth muscle cell apoptotic process
GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_1904761	Biological process	negative regulation of myofibroblast differentiation
GO_1904706	Biological process	negative regulation of vascular associated smooth muscle cell proliferation
GO_0043279	Biological process	response to alkaloid
GO_1900016	Biological process	negative regulation of cytokine production involved in inflammatory response
GO_1905064	Biological process	negative regulation of vascular associated smooth muscle cell differentiation
GO_0043508	Biological process	negative regulation of JUN kinase activity
GO_0030509	Biological process	BMP signaling pathway
GO_0009725	Biological process	response to hormone
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0006915	Biological process	apoptotic process
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0060940	Biological process	epithelial to mesenchymal transition involved in cardiac fibroblast development
GO_2000353	Biological process	positive regulation of endothelial cell apoptotic process
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDCD4
Protein name	Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) Programmed cell death protein 4
Synonyms	H731
Description	FUNCTION: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). .
Accessions	Q53EL6 ENST00000444997.1 Q5VZS7 ENST00000280154.12 [Q53EL6-1] ENST00000393104.6 [Q53EL6-2]

PDCD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review