DAPK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043276Biological processanoikis
GO_2000424Biological processpositive regulation of eosinophil chemotaxis
GO_0035556Biological processintracellular signal transduction
GO_0042981Biological processregulation of apoptotic process
GO_0010506Biological processregulation of autophagy
GO_2001242Biological processregulation of intrinsic apoptotic signaling pathway
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0006915Biological processapoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0031410Cellular componentcytoplasmic vesicle
GO_0034423Cellular componentautophagosome lumen
GO_0005794Cellular componentGolgi apparatus
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDAPK2
Protein nameDAPK2 protein
Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1)
Death associated protein kinase 2
Synonyms
DescriptionFUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation . Regulates granulocytic motility by controlling cell spreading and polarization . .; FUNCTION: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.

AccessionsENST00000558064.1
ENST00000559306.1
ENST00000561162.5
ENST00000612884.4 [Q9UIK4-2]
ENST00000559007.5
ENST00000558069.5 [Q9UIK4-2]
H0YL86
H0YMK1
Q1RMF4
Q9UIK4
H0YKW8
ENST00000261891.7 [Q9UIK4-1]
H0YLP5
ENST00000457488.6 [Q9UIK4-1]