GADD45A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033140Biological processnegative regulation of peptidyl-serine phosphorylation of STAT protein
GO_0006281Biological processDNA repair
GO_0071260Biological processcellular response to mechanical stimulus
GO_0046330Biological processpositive regulation of JNK cascade
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0043537Biological processnegative regulation of blood vessel endothelial cell migration
GO_0007098Biological processcentrosome cycle
GO_0016525Biological processnegative regulation of angiogenesis
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0006915Biological processapoptotic process
GO_0071479Biological processcellular response to ionizing radiation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0042770Biological processsignal transduction in response to DNA damage
GO_0051726Biological processregulation of cell cycle
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0019900Molecular functionkinase binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGADD45A
Protein nameGrowth arrest and DNA damage inducible alpha
Growth arrest and DNA damage-inducible protein GADD45 alpha
Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)
Growth arrest and DNA damage inducible alpha (Growth arrest and DNA-damage-inducible 45 alpha)
SynonymsGADD45
DDIT1
DescriptionFUNCTION: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. .

AccessionsENST00000617962.2
A0A087WZQ0
P24522
A0A3B3ITF9
ENST00000650283.1
ENST00000370985.4 [P24522-2]
ENST00000370986.9 [P24522-1]
ENST00000648742.1
A5JUZ3