SIX1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIX1 at tissue level.

III. Associated gene sets

GO_0001658Biological processbranching involved in ureteric bud morphogenesis
GO_0072198Biological processmesenchymal cell proliferation involved in ureter development
GO_0001759Biological processorgan induction
GO_0061197Biological processfungiform papilla morphogenesis
GO_0048741Biological processskeletal muscle fiber development
GO_0048704Biological processembryonic skeletal system morphogenesis
GO_0061551Biological processtrigeminal ganglion development
GO_0030878Biological processthyroid gland development
GO_0072075Biological processmetanephric mesenchyme development
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0014033Biological processneural crest cell differentiation
GO_0061055Biological processmyotome development
GO_0060037Biological processpharyngeal system development
GO_0001657Biological processureteric bud development
GO_0003151Biological processoutflow tract morphogenesis
GO_0072107Biological processpositive regulation of ureteric bud formation
GO_0007519Biological processskeletal muscle tissue development
GO_0007219Biological processNotch signaling pathway
GO_0030855Biological processepithelial cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032880Biological processregulation of protein localization
GO_0048665Biological processneuron fate specification
GO_0001822Biological processkidney development
GO_0014857Biological processregulation of skeletal muscle cell proliferation
GO_2000288Biological processpositive regulation of myoblast proliferation
GO_0051450Biological processmyoblast proliferation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0042472Biological processinner ear morphogenesis
GO_1905243Biological processcellular response to 3,3',5-triiodo-L-thyronine
GO_0010467Biological processgene expression
GO_0042474Biological processmiddle ear morphogenesis
GO_0007605Biological processsensory perception of sound
GO_0072095Biological processregulation of branch elongation involved in ureteric bud branching
GO_0072513Biological processpositive regulation of secondary heart field cardioblast proliferation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0014842Biological processregulation of skeletal muscle satellite cell proliferation
GO_0050678Biological processregulation of epithelial cell proliferation
GO_0048538Biological processthymus development
GO_0090190Biological processpositive regulation of branching involved in ureteric bud morphogenesis
GO_0072193Biological processureter smooth muscle cell differentiation
GO_2000729Biological processpositive regulation of mesenchymal cell proliferation involved in ureter development
GO_0008582Biological processregulation of synaptic assembly at neuromuscular junction
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071599Biological processotic vesicle development
GO_0045664Biological processregulation of neuron differentiation
GO_0030910Biological processolfactory placode formation
GO_0048839Biological processinner ear development
GO_0090103Biological processcochlea morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_2001014Biological processregulation of skeletal muscle cell differentiation
GO_0048699Biological processgeneration of neurons
GO_0090336Biological processpositive regulation of brown fat cell differentiation
GO_0034504Biological processprotein localization to nucleus
GO_0035909Biological processaorta morphogenesis
GO_0006915Biological processapoptotic process
GO_0086100Biological processendothelin receptor signaling pathway
GO_0051451Biological processmyoblast migration
GO_0072172Biological processmesonephric tubule formation
GO_0021610Biological processfacial nerve morphogenesis
GO_0007389Biological processpattern specification process
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001223Molecular functiontranscription coactivator binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding

IV. Literature review

[source]
Gene nameSIX1
Protein nameHomeobox protein SIX1 (Sine oculis homeobox homolog 1)
SIX homeobox 1
Synonyms
DescriptionFUNCTION: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as a transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation . Mediates nuclear translocation of EYA1 and EYA2 . Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer . Regulates the expression of numerous genes, including MYC, CCND1 and EZR (By similarity). Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 . Promotes brown adipocyte differentiation (By similarity). .

AccessionsENST00000645694.3
Q15475
ENST00000554986.2
H0YK85