TNFRSF21 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031642Biological processnegative regulation of myelination
GO_0042552Biological processmyelination
GO_0001783Biological processB cell apoptotic process
GO_0050852Biological processT cell receptor signaling pathway
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0006959Biological processhumoral immune response
GO_0007413Biological processaxonal fasciculation
GO_0002250Biological processadaptive immune response
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0051402Biological processneuron apoptotic process
GO_0032696Biological processnegative regulation of interleukin-13 production
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0048713Biological processregulation of oligodendrocyte differentiation
GO_0006915Biological processapoptotic process
GO_0032714Biological processnegative regulation of interleukin-5 production
GO_0097252Biological processoligodendrocyte apoptotic process
GO_0030889Biological processnegative regulation of B cell proliferation
GO_0005886Cellular componentplasma membrane
GO_0030424Cellular componentaxon
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNFRSF21
Protein nameBM-018 (TNFRSF21 protein)
Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Alternative protein TNFRSF21
SynonymsDR6
UNQ437/PRO868
DescriptionFUNCTION: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC . .

AccessionsO75509
Q9NZD9
ENST00000296861.2
L8E6S5