PIM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902033Biological processregulation of hematopoietic stem cell proliferation
GO_0060045Biological processpositive regulation of cardiac muscle cell proliferation
GO_1905062Biological processpositive regulation of cardioblast proliferation
GO_1990748Biological processcellular detoxification
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0045824Biological processnegative regulation of innate immune response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0090336Biological processpositive regulation of brown fat cell differentiation
GO_0050821Biological processprotein stabilization
GO_0006915Biological processapoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0070561Biological processvitamin D receptor signaling pathway
GO_0046777Biological processprotein autophosphorylation
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0022898Biological processregulation of transmembrane transporter activity
GO_0071346Biological processcellular response to type II interferon
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0043024Molecular functionribosomal small subunit binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0030145Molecular functionmanganese ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIM1
Protein nameSerine/threonine-protein kinase pim-1 (EC 2.7.11.1)
Synonyms
DescriptionFUNCTION: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis . Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3) . Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity (By similarity). The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis (By similarity). Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1 (By similarity). Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis . Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C . Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability . Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels . Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation . May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 . Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (By similarity). Acts as a positive regulator of mTORC1 signaling by mediating phosphorylation and inhibition of DEPDC5 component of the GATOR1 complex . Acts as a negative regulator of innate immunity by mediating phosphorylation and inactivation of GBP1 in absence of infection: phosphorylation of GBP1 induces interaction with 14-3-3 protein sigma (SFN) and retention in the cytosol . Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells . Promotes brown adipocyte differentiation (By similarity). .

AccessionsENST00000373509.6 [P11309-1]
P11309