PRAME report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PRAME at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRAME at tissue level.

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_0048387Biological processnegative regulation of retinoic acid receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030154Biological processcell differentiation
GO_0006915Biological processapoptotic process
GO_0045596Biological processnegative regulation of cell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0042974Molecular functionnuclear retinoic acid receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRAME
Protein nameMelanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)
Melanoma antigen preferentially-expressed in tumors (PRAME nuclear receptor transcriptional regulator)
PRAME nuclear receptor transcriptional regulator
Melanoma antigen preferentially-expressed in tumors
SynonymsMAPE
OIP4
DescriptionFUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation . The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding . In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation . Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis . .

AccessionsENST00000438888.5
ENST00000630573.2
ENST00000398743.6
ENST00000617728.4
ENST00000398741.5
P78395
ENST00000631267.1
H7C2P3
ENST00000403441.1
E7EW99
A0A0G2JRX8
ENST00000420709.5
ENST00000627660.2
ENST00000626772.2
ENST00000402697.5
ENST00000628830.2
ENST00000626503.2
ENST00000406503.1
B5MD04
ENST00000630407.2
E7EMH2
B5MCY4
ENST00000543184.5
ENST00000405655.8
ENST00000539862.2
A0A0G2JRX7
ENST00000439106.5