TMBIM4 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
fibroblast	25 studies	35% ± 16%	Explore
macrophage	25 studies	35% ± 16%	Explore
endothelial cell	24 studies	38% ± 15%	Explore
B cell	20 studies	32% ± 12%	Explore
non-classical monocyte	18 studies	48% ± 19%	Explore
classical monocyte	18 studies	38% ± 15%	Explore
natural killer cell	17 studies	27% ± 6%	Explore
CD4-positive, alpha-beta T cell	17 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	17 studies	26% ± 8%	Explore
conventional dendritic cell	16 studies	35% ± 17%	Explore
pericyte	16 studies	28% ± 9%	Explore
mast cell	15 studies	32% ± 10%	Explore
ciliated cell	14 studies	41% ± 20%	Explore
endothelial cell of lymphatic vessel	14 studies	43% ± 15%	Explore
smooth muscle cell	12 studies	31% ± 8%	Explore
regulatory T cell	12 studies	28% ± 7%	Explore
myofibroblast cell	11 studies	29% ± 14%	Explore
monocyte	11 studies	36% ± 12%	Explore
myeloid cell	11 studies	31% ± 13%	Explore
plasma cell	10 studies	30% ± 12%	Explore
naive B cell	10 studies	26% ± 7%	Explore
dendritic cell	10 studies	42% ± 25%	Explore
epithelial cell	10 studies	39% ± 22%	Explore
capillary endothelial cell	9 studies	32% ± 9%	Explore
connective tissue cell	9 studies	34% ± 14%	Explore
endothelial cell of artery	9 studies	33% ± 12%	Explore
vein endothelial cell	9 studies	33% ± 11%	Explore
gamma-delta T cell	9 studies	26% ± 7%	Explore
plasmacytoid dendritic cell	9 studies	31% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	24% ± 6%	Explore
mature NK T cell	8 studies	29% ± 6%	Explore
memory B cell	8 studies	26% ± 4%	Explore
microglial cell	8 studies	31% ± 12%	Explore
basal cell	8 studies	43% ± 22%	Explore
T cell	8 studies	27% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	26% ± 7%	Explore
mesothelial cell	7 studies	32% ± 19%	Explore
mucosal invariant T cell	7 studies	25% ± 6%	Explore
astrocyte	7 studies	30% ± 12%	Explore
secretory cell	7 studies	34% ± 19%	Explore
endothelial cell of vascular tree	7 studies	37% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	29% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	30% ± 6%	Explore
oligodendrocyte	6 studies	25% ± 8%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 9%	Explore
ionocyte	5 studies	25% ± 10%	Explore
leukocyte	5 studies	31% ± 6%	Explore
progenitor cell	5 studies	24% ± 5%	Explore
alveolar macrophage	5 studies	41% ± 14%	Explore
type I pneumocyte	5 studies	32% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	27% ± 12%	Explore
T follicular helper cell	5 studies	28% ± 6%	Explore
hematopoietic precursor cell	4 studies	29% ± 16%	Explore
plasmablast	4 studies	49% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	23% ± 4%	Explore
mononuclear phagocyte	4 studies	46% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	31% ± 6%	Explore
epithelial cell of proximal tubule	4 studies	21% ± 5%	Explore
kidney loop of Henle epithelial cell	4 studies	34% ± 12%	Explore
abnormal cell	4 studies	31% ± 12%	Explore
goblet cell	4 studies	33% ± 16%	Explore
lymphocyte	4 studies	28% ± 6%	Explore
retina horizontal cell	4 studies	21% ± 4%	Explore
adventitial cell	4 studies	29% ± 18%	Explore
type II pneumocyte	4 studies	47% ± 20%	Explore
Mueller cell	4 studies	33% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	28% ± 11%	Explore
neutrophil	4 studies	22% ± 8%	Explore
intestinal crypt stem cell	4 studies	22% ± 9%	Explore
T-helper 17 cell	4 studies	25% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	24% ± 5%	Explore
pancreatic A cell	3 studies	50% ± 20%	Explore
pancreatic D cell	3 studies	61% ± 23%	Explore
type B pancreatic cell	3 studies	49% ± 25%	Explore
exhausted T cell	3 studies	33% ± 10%	Explore
renal alpha-intercalated cell	3 studies	49% ± 15%	Explore
common myeloid progenitor	3 studies	31% ± 16%	Explore
hematopoietic stem cell	3 studies	25% ± 7%	Explore
brush cell	3 studies	33% ± 13%	Explore
retinal cone cell	3 studies	41% ± 10%	Explore
retinal rod cell	3 studies	28% ± 12%	Explore
mucus secreting cell	3 studies	42% ± 5%	Explore
serous secreting cell	3 studies	35% ± 14%	Explore
tissue-resident macrophage	3 studies	29% ± 4%	Explore
intraepithelial lymphocyte	3 studies	28% ± 7%	Explore
rod bipolar cell	3 studies	26% ± 5%	Explore
respiratory goblet cell	3 studies	31% ± 20%	Explore
intermediate monocyte	3 studies	39% ± 25%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	39% ± 15%	Explore
granulocyte	3 studies	35% ± 16%	Explore
innate lymphoid cell	3 studies	26% ± 4%	Explore
enteroendocrine cell	3 studies	38% ± 18%	Explore
CD4-positive helper T cell	3 studies	26% ± 8%	Explore
transit amplifying cell	3 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	19% ± 3%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	35% ± 12%	Explore
lung	11 studies	40% ± 16%	Explore
intestine	8 studies	29% ± 14%	Explore
kidney	5 studies	26% ± 11%	Explore
brain	5 studies	34% ± 9%	Explore
placenta	4 studies	24% ± 5%	Explore
eye	4 studies	28% ± 10%	Explore
uterus	4 studies	38% ± 6%	Explore
pancreas	3 studies	51% ± 21%	Explore
bone marrow	3 studies	22% ± 8%	Explore
lymph node	3 studies	23% ± 6%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	3490.13	245 / 245	99%	18.25	499 / 502
thymus	100%	4352.52	653 / 653	99%	21.55	601 / 605
kidney	100%	3569.44	89 / 89	99%	15.76	892 / 901
adrenal gland	100%	5713.45	258 / 258	99%	16.44	227 / 230
brain	98%	1620.57	2601 / 2642	99%	11.52	699 / 705
breast	100%	4655.69	459 / 459	97%	17.33	1083 / 1118
ovary	100%	3316.49	180 / 180	97%	10.75	415 / 430
stomach	100%	3449.01	359 / 359	95%	10.38	273 / 286
lung	100%	4142.62	578 / 578	95%	12.01	1099 / 1155
pancreas	100%	2796.27	328 / 328	95%	11.37	169 / 178
uterus	100%	3823.18	170 / 170	94%	8.97	432 / 459
intestine	100%	3651.63	966 / 966	93%	10.26	491 / 527
bladder	100%	3565.81	21 / 21	92%	9.14	465 / 504
liver	100%	2558.41	226 / 226	92%	10.96	373 / 406
esophagus	100%	2992.11	1445 / 1445	92%	11.17	168 / 183
skin	100%	2791.41	1808 / 1809	89%	10.34	422 / 472
adipose	100%	4555.12	1204 / 1204	0%	0	0 / 0
spleen	100%	4318.44	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	5.98	1 / 1
blood vessel	100%	3913.55	1334 / 1335	0%	0	0 / 0
heart	99%	2414.26	854 / 861	0%	0	0 / 0
muscle	99%	1840.02	791 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	9.60	28 / 29
peripheral blood	95%	3302.72	885 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	7.78	41 / 45
eye	0%	0	0 / 0	79%	7.61	63 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0