DUX4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DUX4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DUX4 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0070317Biological processnegative regulation of G0 to G1 transition
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameDUX4
Protein nameDouble homeobox 4 isoform DUX4-fl
Double homeobox protein 4 (Double homeobox protein 10)
DUX4
SynonymsDUX4L
DUX10
DescriptionFUNCTION: [Isoform 1]: Transcription factor that is selectively and transiently expressed in cleavage-stage embryos . Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3' . Binds to chromatin containing histone H3 acetylated at 'Lys-27' (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, binds to chromatin that lacks histone H3 acetylation at 'Lys-27' (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at 'Lys-27' at new sites . Involved in transcriptional regulation of numerous genes, primarily as transcriptional activator, but mediates also repression of a set of target genes . Promotes expression of ZSCAN4 and KDM4E, two proteins with essential roles during early embryogenesis . Heterologous expression in cultured embryonic stem cells mediates also transcription of HERVL retrotransposons and transcripts derived from ACRO1 and HSATII satellite repeats . May activate expression of PITX1 . May regulate microRNA (miRNA) expression . Inappropriate expression can inhibit myogenesis and promote apoptosis . .; FUNCTION: [Isoform 2]: Probably inactive as a transcriptional activator, due to the absence of the C-terminal region that is important for transcriptional activation. Can inhibit transcriptional activation mediated by isoform 1. Heterologous expression of isoform 2 has no deleterious effect on cell survival. .

AccessionsE0YLM6
E0Z3E7
E0Z3E9
E0Z3F1
F8QWT8
C3U395
F8QWU1
E0Z3F7
C3U397
ENST00000637517.3 [Q9UBX2-1]
ENST00000570263.5 [Q9UBX2-2]
E0Z3G4
F8QWU2
E0Z3E8
ENST00000565211.1 [Q9UBX2-1]
E0Z3F0
Q9UBX2
ENST00000710433.1 [Q9UBX2-1]
C3U399
ENST00000710434.1 [Q9UBX2-2]
A0A2H4V0R9
E0Z3F3
C3U398
A0A8G1DRA9
E0Z3H5
ENST00000616166.1 [Q9UBX2-1]
C3U3A0
ENST00000569241.5 [Q9UBX2-1]
E0Z3H0
E0Z3H2
C3U396
F8QWU0