RRP1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034260Biological processnegative regulation of GTPase activity
GO_0006397Biological processmRNA processing
GO_0098586Biological processcellular response to virus
GO_0008380Biological processRNA splicing
GO_0043923Biological processpositive regulation by host of viral transcription
GO_0006915Biological processapoptotic process
GO_0043484Biological processregulation of RNA splicing
GO_0043065Biological processpositive regulation of apoptotic process
GO_0006364Biological processrRNA processing
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0001652Cellular componentgranular component
GO_0000792Cellular componentheterochromatin
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0030688Cellular componentpreribosome, small subunit precursor
GO_0005829Cellular componentcytosol
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRRP1B
Protein nameRibosomal RNA processing protein 1 homolog B (RRP1-like protein B)
RRP1B protein
SynonymsKIAA0179
DescriptionFUNCTION: Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 . Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus . Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure . .; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. .

AccessionsQ14684
ENST00000340648.6 [Q14684-1]
Q6PJM8