IL24 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL24 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL24 at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0030336Biological processnegative regulation of cell migration
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0071353Biological processcellular response to interleukin-4
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL24
Protein nameInterleukin 24
Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein)
SynonymsST16
MDA7
DescriptionFUNCTION: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis . Possesses antiviral functions and induces the type I interferon response during influenza infection . Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 . In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 . Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). .

AccessionsQ13007
ENST00000611909.4 [Q13007-4]
ENST00000367095.7
ENST00000367093.3 [Q13007-3]
ENST00000391929.7 [Q13007-2]
E7ER64
E7ETP6
ENST00000294984.7 [Q13007-1]
ENST00000480741.1