RPS6KB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014732Biological processskeletal muscle atrophy
GO_0033574Biological processresponse to testosterone
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0045948Biological processpositive regulation of translational initiation
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0003009Biological processskeletal muscle contraction
GO_0032869Biological processcellular response to insulin stimulus
GO_0009749Biological processresponse to glucose
GO_0007616Biological processlong-term memory
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0007165Biological processsignal transduction
GO_0031929Biological processTOR signaling
GO_0043201Biological processresponse to L-leucine
GO_0031670Biological processcellular response to nutrient
GO_0033762Biological processresponse to glucagon
GO_0014878Biological processresponse to electrical stimulus involved in regulation of muscle adaptation
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0034612Biological processresponse to tumor necrosis factor
GO_0045471Biological processresponse to ethanol
GO_0071363Biological processcellular response to growth factor stimulus
GO_0014911Biological processpositive regulation of smooth muscle cell migration
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0031667Biological processresponse to nutrient levels
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007281Biological processgerm cell development
GO_0048633Biological processpositive regulation of skeletal muscle tissue growth
GO_0044539Biological processlong-chain fatty acid import into cell
GO_0046324Biological processregulation of glucose import
GO_0045727Biological processpositive regulation of translation
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0001662Biological processbehavioral fear response
GO_0006915Biological processapoptotic process
GO_0009612Biological processresponse to mechanical stimulus
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0009636Biological processresponse to toxic substance
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0016477Biological processcell migration
GO_0032496Biological processresponse to lipopolysaccharide
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0071346Biological processcellular response to type II interferon
GO_0098978Cellular componentglutamatergic synapse
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0098794Cellular componentpostsynapse
GO_0043005Cellular componentneuron projection
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004711Molecular functionribosomal protein S6 kinase activity
GO_0042277Molecular functionpeptide binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0030165Molecular functionPDZ domain binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPS6KB1
Protein nameRibosomal protein S6 kinase B1
RPS6KB1 protein
Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)
SynonymsSTK14A
DescriptionFUNCTION: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression . Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD . Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex . Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation . The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B . Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis . Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR . In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 . Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling . Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR . Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex . The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function . Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 . In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B . May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR . Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition . .

AccessionsENST00000472940.5
ENST00000225577.9 [P23443-1]
K7EMM2
ENST00000592726.1
ENST00000406116.7 [P23443-4]
K7EIM2
Q4G0X7
P23443
ENST00000393021.7 [P23443-3]
ENST00000443572.6 [P23443-5]
ENST00000489824.1
K7ER06