UNC5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0038007Biological processnetrin-activated signaling pathway
GO_0001525Biological processangiogenesis
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0033564Biological processanterior/posterior axon guidance
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0045121Cellular componentmembrane raft
GO_0005886Cellular componentplasma membrane
GO_0005042Molecular functionnetrin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUNC5B
Protein nameNetrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
SynonymsUNC5H2
P53RDL1
UNQ1883/PRO4326
DescriptionFUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as a netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand . Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity). .

AccessionsENST00000373192.4 [Q8IZJ1-2]
Q8IZJ1
ENST00000335350.10 [Q8IZJ1-1]